Document Detail

Urinary methylmalonic acid excretion in infants fed formula or human milk.
MedLine Citation:
PMID:  2305705     Owner:  NLM     Status:  MEDLINE    
Serum vitamin B-12 and urinary methylmalonic acid (MMA) concentrations were determined in 62 healthy infants aged 1-6 mo. Urinary MMA was inversely correlated with serum vitamin B-12 concentrations (r = -0.550, p less than 0.001); serum vitamin B-12 was higher (p less than 0.001) and urinary MMA concentrations were lower (p less than 0.001) in formula-fed infants than in infants fed human milk (from the breast). Human-milk-fed infants who had received supplemental formula had higher serum vitamin B-12 concentrations than did infants exclusively fed human milk. It is not clear whether the serum vitamin B-12 and urinary MMA concentrations in infants fed human milk reflect biochemical deficiency of vitamin B-12, and the clinical significance of these findings needs to be investigated.
B L Specker; W Brazerol; M L Ho; E J Norman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  51     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-03-21     Completed Date:  1990-03-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  209-11     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Cincinnati Medical Center, OH 45267-0541.
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MeSH Terms
Gas Chromatography-Mass Spectrometry
Infant Food*
Malonates / urine*
Methylmalonic Acid / urine*
Milk, Human*
Vitamin B 12 / blood
Grant Support
Reg. No./Substance:
0/Malonates; 516-05-2/Methylmalonic Acid; 68-19-9/Vitamin B 12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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