| Urinary metabolites as biomarkers of polyphenol intake in humans: a systematic review. | |
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MedLine Citation:
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PMID: 20810980 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To identify associations between polyphenol intake and health and disease outcomes in cohort studies, it is important to identify biomarkers of intake for the various compounds commonly consumed as part of the diet. OBJECTIVE: The objective of this systematic review was to assess the usefulness of polyphenol metabolites excreted in urine as biomarkers of polyphenol intake in humans. DESIGN: The method included a structured search strategy for polyphenol intervention studies on Ovid MEDLINE, EMBASE (Ovid), and Cochrane databases; formal inclusion and exclusion criteria; data extraction into an Access database; validity assessment; and meta-analysis. RESULTS: One hundred sixty-two controlled intervention studies with polyphenols were included, and mean recovery yield and correlations with the dose ingested were determined for 40 polyphenols. Polyphenols such as daidzein, genistein, glycitein, enterolactone, and hydroxytyrosol showed both a high recovery yield (12-37%) and a high correlation with the dose (Pearson's correlation coefficients: 0.67-0.87), which showed good sensitivity and robustness as biomarkers of intake throughout the different studies. Weaker recovery for anthocyanins (0.06-0.2%) and weaker correlations with dose [Pearson's correlation coefficients: 0.21-0.52 for hesperidin, naringenin, (-)-epicatechin, (-)-epigallocatechin, quercetin, and 3 microbial metabolites of isoflavones (dihydrodaidzein, equol, and O-desmethylangolensin)] suggest that they are currently less suitable as biomarkers of intake. CONCLUSIONS: These data confirm the value of certain urinary polyphenols as biomarkers of intake. A validation in populations is now needed to evaluate their specificity, sensitivity, and responsiveness to dose under free-living conditions. |
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Authors:
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Jara Pérez-Jiménez; Jane Hubert; Lee Hooper; Aedin Cassidy; Claudine Manach; Gary Williamson; Augustin Scalbert |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-09-01 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 92 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-21 Completed Date: 2010-10-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 801-9 Citation Subset: AIM; IM |
Affiliation:
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Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, Clermont-Ferrand, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anthocyanins
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metabolism Biological Markers / metabolism, urine Eating Flavanones / metabolism Flavonoids / metabolism*, urine* Humans Phenols / metabolism*, urine* Review Literature as Topic Stilbenes / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Anthocyanins; 0/Biological Markers; 0/Flavanones; 0/Flavonoids; 0/Phenols; 0/Stilbenes; 0/polyphenols |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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