Document Detail


Urinary metabolite levels in workers handling p-tert-butylphenol as an index of personal exposure.
MedLine Citation:
PMID:  2777389     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Occupational exposure to p-tert-butylphenol (PTBP) was studied in a workplace where workers were engaged in packing this alkylphenol in bags or transporting the bags by fork-lift. The geometrical mean of eight-hour-time-weighted-average (8 h-TWA) value for personal ambient PTBP level of the packers was 0.39 mg/m3 (n = 15), higher than that of the carriers (0.10 mg/m3, n = 5). Amounts of PTBP collected in the respirators used by the workers were in proportion to the 8 h-TWA values but lower than the estimated theoretical amounts; considerable amounts of PTBP were assumed to be absorbed through the respiratory tract. The urine excreted during the latter half of the shift showed the highest levels of PTBP (geometrical mean: packer, 5.07 micrograms/ml, n = 20; carrier, 3.03 micrograms/ml, n = 8). When the workers were away from the workplace, PTBP levels decreased; most was excreted within 24 h. Correlation between the urinary PTBP levels and 8 h-TWA values was significant (r = 0.46, n = 19, P less than 0.05), but its extent was weak. The total amounts of urinary PTBP excreted for 24 h after the start of the shift were two to three times higher than the estimated respiratory absorption of PTBP; PTBP was assumed to be absorbed not only through the respiratory tract but also through intact skin. It was concluded that the personal ambient PTBP level is not a suitable index for personal exposure, and biological monitoring via the PTBP level in the urine excreted at the end of the each shift is useful for the evaluation of personal exposure.
Authors:
M Kosaka; T Ueda; M Yoshida; I Hara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International archives of occupational and environmental health     Volume:  61     ISSN:  0340-0131     ISO Abbreviation:  Int Arch Occup Environ Health     Publication Date:  1989  
Date Detail:
Created Date:  1989-10-19     Completed Date:  1989-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7512134     Medline TA:  Int Arch Occup Environ Health     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  451-5     Citation Subset:  IM    
Affiliation:
Department of Public Health, Kansai Medical University, Osaka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Air Pollutants, Occupational / urine*
Environmental Monitoring / methods
Humans
Male
Monitoring, Physiologic
Phenols / urine*
Respiratory Protective Devices
Sweat / analysis
Time Factors
Chemical
Reg. No./Substance:
0/Air Pollutants, Occupational; 0/Phenols; 98-54-4/butylphen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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