Document Detail


Urinary metabolic profiling identifies a key role for glycocholic acid in human liver cancer by ultra-performance liquid-chromatography coupled with high-definition mass spectrometry.
MedLine Citation:
PMID:  23313056     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Metabolomics has been proposed to be a hallmark of cancer, yet a systematic characterization of a metabolite and metabolic pathways in human hepatocarcinoma (HCC) remains challenge. METHODS: Using ultra-performance liquid-chromatography/quadrupole-time-of-flight coupled with high-definition mass spectrometry (UPLC-Q-TOF-HDMS) in conjunction with multivariate data analysis methods, we identified and measured the metabolite profile of glycocholic acid from urine samples obtained from patients with HCC diseases. Bioinformatic tools were used to construct the metabolites network that can identify a key role for glycocholic acid in HCC. RESULTS: Biochemical analyses revealed that glycocholic acid expression was up-regulated in urine samples associated with HCC. Its pathway analysis suggested the modulation of multiple vital physiological pathways, including primary bile acid biosynthesis, secondary bile acid biosynthesis, metabolic pathways, bile secretion. The network generation clearly enhances the interpretation and understanding of mechanisms for glycocholic acid. CONCLUSIONS: Metabolomics can contribute to evaluating the potential of metabolites in HCC patients and may provide new insight into pathophysiologic mechanisms.
Authors:
Xijun Wang; Aihua Zhang; Hui Sun; Guangli Yan; Ying Han; Yuan Ye
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-8
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  -     ISSN:  1873-3492     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
National TCM Key Lab of Serum Pharmacochemistry, Key Pharmacometabolomics Platform of Chinese Medicines and Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China. Electronic address: xijunwangls@126.com.
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