| Urinary mandelic acid concentration after occupational exposure to styrene and its use as a biological exposure test. | |
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MedLine Citation:
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PMID: 1273564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Excretion of mandelic acid from workers in the reinforced polyester plastic industry was studied with the determination of urinary mandelic acid concentrations. The styrene exposure level at the workplaces was evaluated with measurements of the styrene concentration in the ambient air. Three different groups (I, II and III) were studied. In group I [n=9, median of the time-weighted average (TWA) of exposure = 23 ppmof styrene, postexposure observation period = 64 h] two excretion slopes were observed, the first with a median half-time of 9.4 h (postexposure period 0--18 h) and a second with a median half-time of 16.6 h (postexposure period 19--64 h). For group II (n=9, median TWA exposure = 248 ppm, postexposure observation period = 15 h) a half-time of 6.4 h was found. These results suggest that the excretion rate of mandelic acid is dependent on the styrene exposure level. In addition the mandelic acid concentrations of 29 workers (group III) before and after the work shift were analyzed. The urinary mandelic acid concentrations of groups I, II and III, sampled immediately after the 8-h work shift, correlated with the 8-h TWA of styrene exposure (n=47, r=0.93). Accordingly about 2,300 mg of mandelic acid per gram of creatinine corresponded to 100 ppm of styrene. |
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Authors:
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K Engström; H Härkönen; P Kalliokoski; J Rantanen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of work, environment & health Volume: 2 ISSN: 0355-3140 ISO Abbreviation: Scand J Work Environ Health Publication Date: 1976 Mar |
Date Detail:
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Created Date: 1976-08-02 Completed Date: 1976-08-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7511540 Medline TA: Scand J Work Environ Health Country: FINLAND |
Other Details:
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Languages: eng Pagination: 21-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Air Pollutants, Occupational
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analysis Chemical Industry* Environmental Exposure* Humans Mandelic Acids / urine* Occupational Medicine Plastics Styrenes* / metabolism Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Air Pollutants, Occupational; 0/Mandelic Acids; 0/Plastics; 0/Styrenes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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