Document Detail

Urinary loss of oxypurines in hypoxic premature neonates.
MedLine Citation:
PMID:  7388088     Owner:  NLM     Status:  MEDLINE    
The daily urinary excretion of the oxypurines hypoxanthine, xanthine and uric acid during each of the first 3 days of life was determined in premature infants without hypoxia (PI) and in hypoxic premature infants (HPI) with the respiratory distress syndrome. The loss of uric aic was statistically significantly greater in the HPI during days 1, 2, and 3 of life, and so was the loss of xanthine on days 1, and 2, but not on day 3. As to the loss of hypoxanthine, no difference could be shown. In both groups of infants the excretion of hypoxanthine and xanthine together made up about 2% of the total oxypurine loss for each day, the loss of xanthine being the greater of the two. The results did not seem to bear relation to differences between the two groups concerning urinary output, birth weight, gestational age, method of delivery, or administration of exogenic purines. So it appears that the increased loss of oxypurines in HPI is caused by the impact of hypoxia, probably owing to be compromised cellular respiration with a subsequent general displacement of the purine metabolism in the catabolic direction.
M H Jensen; M M Brinkløv; K Lillquist
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  38     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1980  
Date Detail:
Created Date:  1980-09-26     Completed Date:  1980-09-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  40-8     Citation Subset:  IM    
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MeSH Terms
Anoxia / urine*
Apgar Score
Cesarean Section
Hypoxanthines / urine*
Infant, Newborn
Infant, Premature*
Labor, Obstetric
Respiratory Distress Syndrome, Newborn / urine
Uric Acid / urine*
Xanthines / urine*
Reg. No./Substance:
0/Hypoxanthines; 0/Xanthines; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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