Document Detail

Urinary leukotrienes in patients with nasal polyposis.
MedLine Citation:
PMID:  18439470     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To compare urinary leukotriene E4 (ULT) level in patients with nasal polyposis (NP) with and without aspirin intolerance and allergic rhinitis (AR), and correlate it with disease severity. STUDY DESIGN AND SETTING: Prospective study from November 2005 to November 2006. Patients with NP (n = 30) and AR (n = 35) were included. The concentration of ULT was measured in both groups. Oral provocation test with aspirin was performed to patients with NP. ULT level between both groups was compared and correlated with NP disease severity. RESULTS: ULT concentration was elevated on NP and AR. The patients with NP and aspirin intolerance (n = 4) presented higher levels of ULT compared to aspirin-tolerant patients. Leukotriene concentration was not correlated with NP severity. CONCLUSIONS: Patients with NP and aspirin intolerance have increased ULT excretion; thus their measurement can be used as an indicator of arachidonic acid metabolism alteration.
Michel Royer; María Antonieta Guzmán; Juan-Pablo Gormaz; Gonzalo Nazar
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery     Volume:  138     ISSN:  0194-5998     ISO Abbreviation:  Otolaryngol Head Neck Surg     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-28     Completed Date:  2008-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508176     Medline TA:  Otolaryngol Head Neck Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  633-6     Citation Subset:  IM    
Department of Otolaryngology, Head and Neck Surgery, Hospital Clínico Universidad de Chile, Santiago, Chile.
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MeSH Terms
Leukotriene E4 / urine*
Middle Aged
Nasal Polyps / urine*
Prospective Studies
Reg. No./Substance:
75715-89-8/Leukotriene E4

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