Document Detail


Urinary leukotriene E4 and 9 alpha, 11 beta-prostaglandin F concentrations in mild, moderate and severe asthma, and in healthy subjects.
MedLine Citation:
PMID:  15080817     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Airway inflammation in asthma is associated with cysteinyl leukotriene and prostaglandin D(2) production. Measurement of urinary metabolites of these eicosanoids may be useful for monitoring asthma patients. However, the influence of asthma phenotype and severity on basal urinary excretion of these metabolites is unknown. OBJECTIVE: To compare urinary leukotriene (LT)E(4) and 9 alpha, 11 beta-prostaglandin (PG)F(2) concentrations in large groups of mild, moderate and severe asthmatic patients and healthy control subjects. METHODS: Asthma severity, treatment and aspirin sensitivity were assessed by questionnaire in 168 asthmatic patients. Basal LTE(4) and 9 alpha, 11 beta-PGF(2) concentrations were measured in urine samples from these patients and from 175 control subjects using enzyme immunoassays. RESULTS: Urinary LTE(4) was correlated with 9 alpha, 11 beta-PGF(2) in both control subjects and asthmatic patients (P<0.002). Median LTE(4) and 9 alpha, 11 beta-PGF(2) concentrations in patients with severe asthma were significantly reduced compared with mild asthmatic patients (P<0.05 and <0.001, respectively). Urinary 9 alpha, 11 beta-PGF(2), but not LTE(4) was lower in asthmatic patients using inhaled corticosteroids (P<0.02). Multiple regression analysis indicated that urinary 9 alpha, 11 beta-PGF(2) concentration was negatively correlated with asthma severity (P=0.003) and also with % predicted FEV(1) (forced expiratory volume in 1 s) (P=0.005). CONCLUSIONS: Baseline urinary LTE(4) and 9 alpha, 11 beta-PGF(2) concentrations are of limited value in discriminating between patients with different severities of asthma. Reduced urinary LTE(4) and 9 alpha, 11 beta-PGF(2) in patients with severe asthma suggest that direct or indirect effects of high-dose corticosteroid therapy combined with other factors associated with severe asthma may influence eicosanoid production. However, the negative association of urinary 9 alpha, 11 beta-PGF(2) with lung function suggests an adverse effect of chronic PGD(2) production on lung function in asthma, irrespective of severity.
Authors:
N L A Misso; S Aggarwal; S Phelps; R Beard; P J Thompson
Related Documents :
9612667 - Steroid therapy for chronic obstructive pulmonary disease.
22560507 - Vocal characteristics in patients with thyroiditis.
6360257 - The role of protriptyline in obstructive sleep apnea.
20671307 - Exhaled nitric oxide thresholds associated with a sputum eosinophil count ≥3% in a co...
24963647 - Investigation of genotoxicity in acromegaly from peripheral blood lymphocyte cultures u...
22982967 - Transforming growth factor ß1 level and outcome after catheter ablation for non-paroxy...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  34     ISSN:  0954-7894     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-14     Completed Date:  2004-07-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  England    
Other Details:
Languages:  eng     Pagination:  624-31     Citation Subset:  IM    
Affiliation:
Cooperative Research Centre for Asthma, The University of Western Australia, Perth, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Asthma / drug therapy,  urine*
Biological Markers / urine
Dinoprost / urine*
Female
Glucocorticoids / therapeutic use
Humans
Leukotriene E4 / urine*
Male
Middle Aged
Regression Analysis
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Glucocorticoids; 551-11-1/Dinoprost; 75715-89-8/Leukotriene E4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Relationship of airway symptoms from chemicals to capsaicin cough sensitivity in atopic subjects.
Next Document:  Efficacy and safety of a recombinant anti-immunoglobulin E antibody (omalizumab) in severe allergic ...