Document Detail

Urinary kallikrein: a marker of blood pressure sensitivity to salt.
MedLine Citation:
PMID:  8731109     Owner:  NLM     Status:  MEDLINE    
We evaluated if a rat strain inbred for low urinary kallikrein excretion differs from normal-kallikrein Wistar rats regarding blood pressure levels in basal conditions and during alterations in sodium balance. Blood pressure was measured in unanesthetized rats on normal sodium intake. Then, blood pressure sensitivity to salt was evaluated over a period of 20 days of high sodium diet (0.84 mmol per g chow). Low-kallikrein rats showed greater systolic blood pressure levels (125 +/- 3 vs. 114 +/- 2 mm Hg in controls, P < 0.01) at nine weeks of age. Systolic blood pressure was increased after sodium loading in the low-kallikrein group and remained unchanged in controls (150 +/- 6 vs. 112 +/- 2 mm Hg, P < 0.01). This effect was associated with a reduced cumulative urinary excretion of sodium in the low-kallikrein rats. No group difference was found in the clearance of endogenous creatinine in basal conditions. Urinary creatinine excretion decreased during sodium loading, particularly in the low-kallikrein group. The group-difference in urinary kallikrein excretion found in basal conditions (6.85 +/- 0.31 vs. 20.74 +/- 1.71 nkat/24 hr in controls, P < 0.01) was enhanced by high salt diet (2.96 +/- 0.67 vs. 22.07 +/- 2.47 nkat/24 hr in controls, P < 0.01). In addition, renal kallikrein activity and content were reduced in low-kallikrein rats. The latter group showed a greater ratio of heart weight to body wt both in basal conditions and after sodium loading. The ratio of kidney weight to body wt was reduced after sodium loading. These results indicate that a genetically-determined defect in urinary kallikrein excretion is associated with a greater blood pressure sensitivity to salt, possibly due to altered renal sodium handling.
P Madeddu; M V Varoni; M P Demontis; P Pinna-Parpaglia; N Glorioso; V Anania
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Kidney international     Volume:  49     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-10-22     Completed Date:  1996-10-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1422-7     Citation Subset:  IM    
Clinica Medica and Farmacologia, University of Sassari, Italy.
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MeSH Terms
Biological Markers / urine
Blood Pressure / drug effects*,  physiology
Drug Resistance
Kallikreins / metabolism,  urine*
Kidney / metabolism
Rats, Wistar
Sodium Chloride / pharmacology*
Sodium, Dietary / administration & dosage
Reg. No./Substance:
0/Biological Markers; 0/Sodium, Dietary; 7647-14-5/Sodium Chloride; EC 3.4.21.-/Kallikreins

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