Document Detail

Urinary kallikrein in normotensive subjects and in patients with essential hypertension.
MedLine Citation:
PMID:  396074     Owner:  NLM     Status:  MEDLINE    
1. Excretion of urinary kallikrein was normal in 13 out of 15 patients with uncomplicated essential hypertension. 2. Frusemide increased urinary kallikrein excretion in normotensive subjects and in patients with essential hypertension. The stimulating effect of frusemide on urinary kallikrein was significantly diminished in patients with essential hypertension. 3. No correlations of urinary kallikrein with sodium, potassium, and aldosterone excretion were found. 4. The results do not support the idea that urinary kallikrein plays a primary role in the pathogenesis of essential hypertension.
H Zschiedrich; P Fleckenstein; R Geiger; E Fink; K Sinterhauf; T Philipp; A Distler; H P Wolff
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  57 Suppl 5     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1979 Dec 
Date Detail:
Created Date:  1980-06-25     Completed Date:  1980-06-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  247s-250s     Citation Subset:  IM    
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MeSH Terms
Aldosterone / urine
Creatinine / metabolism
Furosemide / diagnostic use
Hypertension / enzymology,  urine*
Kallikreins / urine*
Potassium / urine
Renin / blood
Sodium / urine
Reg. No./Substance:
52-39-1/Aldosterone; 54-31-9/Furosemide; 60-27-5/Creatinine; 7440-09-7/Potassium; 7440-23-5/Sodium; EC 3.4.21.-/Kallikreins; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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