| Urinary hypoxanthine, xanthine and uric acid excretion in newborn infants with perinatal complications. | |
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MedLine Citation:
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PMID: 411324 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The concentration of hypoxanthine, xanthine and uric acid in the first 24-h urine of 105 newborn infants was measured densitometrically by thin-layer chromatography. 45 of them had moderate or severe perinatal complications. Among these newborns, 26 infants with perinatal complications (58%) and 4 infants without perinatal complications (7%) had an elevated urinary excretion rate of hypoxanthine. Urinary xanthine was not increased, uric acid was slightly higher in the group of infants with perinatal complication. It seems that a crucial mark is involved, if the rate of hypoxanthine exceed 15% of the total urinary oxypurine excretion, or, if related to urinary creatinine, more than 0.075 mumol hypoxanthine/mumol creatinine. Apparently, with hypoxic newborns increased values of urinary hypoxanthine excretion can be used to quantify the lack of oxygen retrospectively. |
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Authors:
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H Manzke; K Dörner; J Grünitz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta paediatrica Scandinavica Volume: 66 ISSN: 0001-656X ISO Abbreviation: Acta Paediatr Scand Publication Date: 1977 Nov |
Date Detail:
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Created Date: 1977-12-29 Completed Date: 1977-12-29 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0000211 Medline TA: Acta Paediatr Scand Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 713-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chromatography, Thin Layer Creatinine / urine Densitometry Female Fetal Hypoxia / diagnosis*, urine Humans Hypoxanthines / urine* Infant, Newborn Infant, Newborn, Diseases / urine* Osmolar Concentration Parenteral Nutrition Pregnancy Uric Acid / urine* Xanthines / urine* |
| Chemical | |
Reg. No./Substance:
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0/Hypoxanthines; 0/Xanthines; 60-27-5/Creatinine; 69-93-2/Uric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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