Document Detail

Urinary hypoxanthine, xanthine and uric acid excretion in newborn infants with perinatal complications.
MedLine Citation:
PMID:  411324     Owner:  NLM     Status:  MEDLINE    
The concentration of hypoxanthine, xanthine and uric acid in the first 24-h urine of 105 newborn infants was measured densitometrically by thin-layer chromatography. 45 of them had moderate or severe perinatal complications. Among these newborns, 26 infants with perinatal complications (58%) and 4 infants without perinatal complications (7%) had an elevated urinary excretion rate of hypoxanthine. Urinary xanthine was not increased, uric acid was slightly higher in the group of infants with perinatal complication. It seems that a crucial mark is involved, if the rate of hypoxanthine exceed 15% of the total urinary oxypurine excretion, or, if related to urinary creatinine, more than 0.075 mumol hypoxanthine/mumol creatinine. Apparently, with hypoxic newborns increased values of urinary hypoxanthine excretion can be used to quantify the lack of oxygen retrospectively.
H Manzke; K Dörner; J Grünitz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  66     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1977 Nov 
Date Detail:
Created Date:  1977-12-29     Completed Date:  1977-12-29     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  713-7     Citation Subset:  IM    
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MeSH Terms
Chromatography, Thin Layer
Creatinine / urine
Fetal Hypoxia / diagnosis*,  urine
Hypoxanthines / urine*
Infant, Newborn
Infant, Newborn, Diseases / urine*
Osmolar Concentration
Parenteral Nutrition
Uric Acid / urine*
Xanthines / urine*
Reg. No./Substance:
0/Hypoxanthines; 0/Xanthines; 60-27-5/Creatinine; 69-93-2/Uric Acid

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