Document Detail


Urinary hydroxyproline in multiple myeloma: correlation with clinical stages and bone disease.
MedLine Citation:
PMID:  6740769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty-four-hour urinary hydroxyproline excretion (HOP) (normal values: 6-22 mg/day/m2) was measured by the Hypronosticon test in 50 untreated patients with plasma cell myeloma. At diagnosis, HOP was elevated in 36 of 50 patients (72%) with a mean value of 35.9 mg/day/m2. Extent of bone lesions and clinical stage were accurately assessed in all patients. Higher HOP values were found in patients with a higher degree of bone lesions (multiple lytic areas and/or destruction of skeletal segments). According to clinical stages, HOP was very elevated only in stage III (mean value: 43.7); in stages I and II the mean value (25.2) was just above the normal range. Our data indicate that HOP in multiple myeloma at diagnosis is closely related to the extension of skeletal lesions and that during the clinical course it may be useful in the follow-up of bone disease.
Authors:
S Bolzonella; A Paccagnella; L Salvagno; V Chiarion Sileni; P De Besi; P Scalella; M V Fiorentino
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Tumori     Volume:  70     ISSN:  0300-8916     ISO Abbreviation:  Tumori     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-08-07     Completed Date:  1984-08-07     Revised Date:  2008-12-12    
Medline Journal Info:
Nlm Unique ID:  0111356     Medline TA:  Tumori     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  249-53     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Bone Diseases / etiology,  urine*
Female
Fractures, Bone / urine
Humans
Hydroxyproline / urine*
Male
Middle Aged
Multiple Myeloma / complications,  pathology,  urine*
Neoplasm Staging
Osteolysis / urine
Osteoporosis / urine
Chemical
Reg. No./Substance:
51-35-4/Hydroxyproline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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