Document Detail

Urinary hMG versus recombinant FSH for controlled ovarian hyperstimulation following an agonist long down-regulation protocol in IVF or ICSI treatment: a systematic review and meta-analysis.
MedLine Citation:
PMID:  18056719     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Since the most recent Cochrane review on hMG versus rFSH for controlled ovarian hyperstimulation following a long down-regulation protocol, several new trials have emerged. METHODS: We conducted a systematic review and meta-analysis of randomized trials comparing the effectiveness of hMG versus rFSH following a long down-regulation protocol in IVF-ICSI cycles, on the primary outcome of live birth per woman randomized, as well as several other secondary outcomes. Searches were conducted in MEDLINE, EMBASE, Science Direct, Cochrane Library and databases of abstracts (last search January 2007). RESULTS: Seven randomized trials, consisting of a total of 2159 randomized women, were identified. A meta-analysis of these trials showed a significant increase in live birth rate with hMG when compared with rFSH (relative risk, RR = 1.18, 95% CI: 1.02-1.38, P = 0.03). The heterogeneity test was non-significant (P = 0.97), suggesting that there was no statistical inconsistency between the seven studies. The pooled risk difference (RD) for the outcome of live birth rate was 4% (95% CI: 1-7%) for these study populations. There was an increase in clinical pregnancy rates with hMG when compared with rFSH (RR = 1.17, 95% CI 1.03-1.34). No significant differences were noted for gonadotrophin use, spontaneous abortion, multiple pregnancy, cancellation and ovarian hyperstimulation syndrome rates. CONCLUSIONS: For the populations in the randomized trials, hMG was associated with a pooled 4% increase in live birth rate when compared with rFSH in IVF-ICSI treatment following a long down-regulation protocol.
Arri Coomarasamy; Masoud Afnan; Deepti Cheema; Fulco van der Veen; Patrick M M Bossuyt; Madelon van Wely
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Publication Detail:
Type:  Comparative Study; Journal Article; Meta-Analysis; Review     Date:  2007-12-03
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  23     ISSN:  1460-2350     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-17     Completed Date:  2008-03-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  310-5     Citation Subset:  IM    
Assisted Conception Unit, 4th Floor, Thomas Guy House, Guys Hospital, Thomas Street, London SE1 9RT, UK.
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MeSH Terms
Birth Rate
Fertilization in Vitro*
Follicle Stimulating Hormone, Human / therapeutic use*
Live Birth
Menotropins / therapeutic use*
Ovulation Induction / methods*
Pregnancy Rate
Randomized Controlled Trials as Topic
Recombinant Proteins / therapeutic use
Sperm Injections, Intracytoplasmic*
Reg. No./Substance:
0/Follicle Stimulating Hormone, Human; 0/Recombinant Proteins; 61489-71-2/Menotropins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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