| Urinary free (unconjugated) metadrenalines in different hereditary forms of catecholamine-secreting phaeochromocytoma/paraganglioma. | |
| | |
MedLine Citation:
|
PMID: 22914444 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Catecholamine-producing neuroendocrine tumours are found in chromaffin cells of the adrenal medulla (phaeochromocytoma) or extra-adrenal paraganglia (paraganglioma), known collectively as PPGLs. In approximately a quarter or more of cases of PPGL, these rare tumours arise as a result of germline mutations of several tumour susceptibility genes. At the Crosshouse laboratory, urine tests include free metadrenalines (fMAs) (also known as free metanephrines) which demonstrate superior sensitivity over that obtained by urinary vanillyl mandelic acid, catecholamines or plasma catecholamines in the diagnosis of PPGL. This retrospective audit was to determine if urinary fMAs offered discrimination among the hereditary forms of PPGL. METHODS: Retrospective biochemical and genetic data were gathered from 1997 to 2011. The identified urine specimens were those obtained at the time of first diagnosis or recurrence of PPGL. Results of catecholamines and metabolites were standardized as multiples of their respective relevant upper reference limits (URLs). RESULTS: Results were available for 29 affected patients (15 females and 14 males), median age 26 (range 9-63) years, comprising three mutation groups: succinate dehydrogenase subunit B or D ([SDHB/D] 16 patients), multiple endocrine neoplasia type 2 ([MEN 2] 6 patients) and von Hippel-Lindau disease ([VHL] 7 patients). The parent catecholamines exhibited increased values for noradrenaline (NA) and/or adrenaline (AD) for 25/29 (86.2%) patients. Either or both free normetadrenaline (fNMA) and fMA were elevated in 29/29 (100%) patients. CONCLUSIONS: The ratio of the multiples of URL for fMA/fNMA displayed a clearer separation of MEN 2 patients from those with SDHB/D or VHL than did the equivalent AD/NA ratio. |
| | |
Authors:
|
D Fraser Davidson; Nicola Bradshaw; Colin G Perry; Robert Lindsay; E Marie Freel |
Related Documents
:
|
19259984 - Blood laboratory findings in patients suffering from self-perceived electromagnetic hyp... 14705174 - Doppler evaluation of the thyroid in pediatric goiter. 16514674 - Black thyroid revisited: cytologic diagnosis in fine-needle aspirates is unlikely. 123294 - Renal cell carcinoma. 21660244 - Effects of thyroid dysfunction on lipid profile. 22954764 - Asymptomatic microscopic hematuria. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-8-22 |
Journal Detail:
|
Title: Annals of clinical biochemistry Volume: - ISSN: 1758-1001 ISO Abbreviation: Ann. Clin. Biochem. Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-8-23 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0324055 Medline TA: Ann Clin Biochem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Biochemistry Department, University Hospital Crosshouse, Kilmarnock KA2 0BE. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: An occult aldosterone-producing adenoma initially presenting as hyperosmolar hyperglycaemic state.
Next Document: News.