| Urinary follicle stimulating hormone can be used as a biomarker to assess male reproductive function. | |
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MedLine Citation:
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PMID: 11225907 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To develop an algorithm for use in population-based studies to assess testicular function by measurements of total urinary follicle stimulating hormone (FSH). METHODS: Total concentrations of urinary FSH were measured in a group of 44 men at the University of California, Davis (UCD) and were compared to FSH measurements in serum. On the basis of these and other published data, a urinary FSH value of >2 ng/mg creatinine (Cr) was selected as the cutoff point to identify men with elevated serum FSH ( > 12 IU/L) or low sperm counts ( < 20 million/mL). RESULTS: The sensitivity and specificity of this algorithm for detecting elevated serum FSH in a group of 58 agricultural workers in the People' s Republic of China were 100% and 50%, respectively. The sensitivity and specificity of this algorithm for detecting low sperm counts in a population of 105 infertility patients at UCD were 58 % and 76 %, respectively. CONCLUSION: This test may have particular value in identifying populations with no evidence of testicular toxicity, and in which labor-intensive semen studies may not be feasible. |
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Authors:
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X R Wang; J W Overstreet; H Todd; Q Qiu; J H Yang; S Y Wang; X P Xu; B L Lasley |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Asian journal of andrology Volume: 1 ISSN: 1008-682X ISO Abbreviation: Asian J. Androl. Publication Date: 1999 Jun |
Date Detail:
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Created Date: 2001-02-27 Completed Date: 2001-04-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100942132 Medline TA: Asian J Androl Country: China |
Other Details:
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Languages: eng Pagination: 67-72 Citation Subset: IM |
Affiliation:
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School of Public Health, Nanjing Medical University, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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urine Follicle Stimulating Hormone / urine* Humans Infertility, Male / diagnosis*, urine* Male Predictive Value of Tests Sensitivity and Specificity |
| Grant Support | |
ID/Acronym/Agency:
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ES04699/ES/NIEHS NIH HHS; ES05707/ES/NIEHS NIH HHS; ES06198/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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