| Urinary follicle-stimulating hormone (FSH) is more effective than recombinant FSH in older women in a controlled randomized study. | |
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MedLine Citation:
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PMID: 16600226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The following study was conducted to determine which FSH, recombinant or urinary, works better in older women. DESIGN: We conducted a controlled randomized study in a single university IVF center. SETTING: University IVF center. PATIENT(S): Women (N = 257) over 39 years old undergoing IVF. INTERVENTION(S): The patients were randomized into two study groups at their first IVF cycle: 121 patients were treated with recombinant FSH, and 120 patients were treated with urinary FSH. Both groups were suppressed with a long GnRH analog protocol. MAIN OUTCOME MEASURE(S): Days of stimulation, E2 at the day of hCG, total amount of FSH administered, number of oocytes collected, amount of FSH per oocyte, and number of embryos obtained. RESULT(S): Patients treated with urinary FSH required a significantly lower total amount of FSH, and a lower amount of FSH per oocyte than women treated with recombinant FSH. The other measures evaluated did not show any statistically significant differences. CONCLUSION(S): Our study showed that urinary FSH performed better in older women than recombinant FSH when associated with the long protocol. |
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Authors:
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Mohamed A Mohamed; Marco Sbracia; Arianna Pacchiarotti; Giulietta Micara; Antonella Linari; Daniela Tranquilli; Salomé M B Espinola; Cesare Aragona |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2006-04-05 |
Journal Detail:
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Title: Fertility and sterility Volume: 85 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-05-01 Completed Date: 2006-05-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1398-403 Citation Subset: IM |
Affiliation:
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Department of Obstetrics, Gynecology and Perinatology, Policlinico Umberto I Hospital, La Sapienza University, Rome, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Combined Modality Therapy / statistics & numerical data Female Fertilization in Vitro / statistics & numerical data* Follicle Stimulating Hormone, Human / administration & dosage*, genetics Humans Incidence Infertility / epidemiology*, therapy* Italy / epidemiology Pregnancy / statistics & numerical data Pregnancy Outcome / epidemiology* Pregnancy Rate* Recombinant Proteins / administration & dosage Treatment Outcome Urofollitropin / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Follicle Stimulating Hormone, Human; 0/Recombinant Proteins; 0/Urofollitropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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