| Urinary excretory ratio of anthranilic acid/kynurenic acid as an index of the tolerable amount of tryptophan. | |
| | |
MedLine Citation:
|
PMID: 18603814 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Some people may take excessive tryptophan as a supplement in the expectation that the tryptophan metabolite, melatonine, will help to induce sufficient sleep. We investigated the basis for a useful index to assess the risk of a tryptophan excess. Young rats were fed on a 20% casein diet with 0, 0.5, 1.0, 2.0 or 5.0% added tryptophan for 30 d the apparent toxicity and growth retardation was observed in the 5.0% tryptophan-added group. Metabolites of the Tryptophan-nicotinamide pathway and such intermediates as kynurenic acid (KA), anthranilic acid (AnA), xanthurenic acid, 3-hydroxyanthranilic acid and quinolinic acid in 24-h urine increased in a dose-dependent manner. Of those metabolites and intermediates, the urinary excretion of KA progressively increased, and that of AnA dramatically increased in the 2.0 and 5.0% tryptophan-added groups. The urinary excretory ratio of AnA/KA was a high value for both the groups. These results suggest that the urinary ratio of AnA/KA could be a useful index to monitoran excessive tryptophan intake. |
| | |
Authors:
|
Alato Okuno; Tsutomu Fukuwatari; Katsumi Shibata |
Related Documents
:
|
10844694 - Identification of a major facilitator protein from escherichia coli involved in efflux ... 1759854 - Evaluation of the effects of chelation therapy with time following strontium exposure t... 857624 - Purine excretion in complete adenine phosphoribosyltransferase deficiency: effect of di... 6434844 - Gas chromatography--mass spectrometry (gc--ms) diagnosis of two cases of medium chain a... 10099424 - Effect of escherichia coli biomass composition on central metabolic fluxes predicted by... 19708004 - Cholestane glycosides and trihydroxy fatty acids from the rhizomes of dioscorea septeml... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-07-07 |
Journal Detail:
|
Title: Bioscience, biotechnology, and biochemistry Volume: 72 ISSN: 1347-6947 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 2008 Jul |
Date Detail:
|
Created Date: 2008-07-23 Completed Date: 2008-09-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: Japan |
Other Details:
|
Languages: eng Pagination: 1667-72 Citation Subset: IM |
Affiliation:
|
Department of Life Style Studies, Laboratories of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 522-8533, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anthranilic Acids / urine* Dietary Supplements Dose-Response Relationship, Drug Kynurenic Acid / urine* Male Rats Rats, Wistar Tryptophan / administration & dosage, metabolism*, toxicity* |
| Chemical | |
Reg. No./Substance:
|
0/Anthranilic Acids; 118-92-3/anthranilic acid; 492-27-3/Kynurenic Acid; 73-22-3/Tryptophan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Oral administration of highly oligomeric procyanidins of Jatoba reduces the severity of collagen-ind...
Next Document: Studies on taste: molecular biology and food science.