| Urinary excretion of vitamin k metabolites in term and preterm infants: relationship to vitamin k status and prophylaxis. | |
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MedLine Citation:
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PMID: 20814348 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Little is known about the metabolic turnover and excretion of vitamin K in healthy newborn infants and the metabolic consequences of prophylactic regimens designed to protect against vitamin K deficiency bleeding (VKDB). We measured the excretion of two urinary metabolites (≤24 h) of vitamin K (5C- and 7C-aglycones) in term infants before (n = 11) and after (n = 5) a 1000 μg i.m. dose of vitamin K1 (K1) and in preterm infants after 200 μg i.m. (n = 4), 500 μg i.m. (n = 4), or 200 μg i.v. (n = 5). In preterm infants, we also measured serum K1, vitamin K1 2,3-epoxide, and PIVKA-II at 5 d postpartum. Before prophylaxis, the rate of 5C- and 7C-aglycone excretion was 25 times lower than adults, reflecting low vitamin K stores at birth. After prophylaxis, the excretion rate correlated to K1 dose (r = 0.6) but was two orders of magnitude lower than that in adults, probably reflecting the immaturity of neonatal catabolism. All term and 10 of 13 preterm infants mainly excreted 5C-aglycone. We present evidence that increased excretion of the 7C-aglycone was associated with metabolic overload because of the exposure to high-tissue K1 concentrations. Measurement of the 5C- and 7C-aglycones may facilitate longitudinal studies of vitamin K status in neonates and aid the development of improved prophylactic regimens. ABBREVIATIONS:: |
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Authors:
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Dominic Jon Harrington; Paul Clarke; David J Card; Simon J Mitchell; Martin J Shearer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric research Volume: 68 ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2011-07-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 508-12 Citation Subset: IM |
Affiliation:
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The Nutristasis Unit [D.J.H., D.J.C., M.J.S.], St. Thomas' Hospital, London SE1 7EH, United Kingdom; Norfolk and Norwich University Hospitals [P.C.], NHS Foundation Trust, Norwich NR4 7UY, United Kingdom; Newborn Intensive Care Unit [S.J.M.], St. Mary's Hospital, Manchester M13 9WL, United Kingdom. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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