| Urinary excretion of thiol conjugates of aflatoxin B1 in rats and hamsters. | |
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MedLine Citation:
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PMID: 6423269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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After intraperitoneal injection of [3H]aflatoxin B1 in rats and hamsters, 24-h urinary excretion of aflatoxin B1 metabolites was examined in these species. Total excretion was 10-15% of the injected dose with hamster excreting 50% more than the rat. In both species, 60% of the total excretion was due to glucuronide and sulfate conjugates of hydroxy metabolites. Striking differences were observed in the excretion of both aflatoxin B1-diol and various thiol conjugates. Aflatoxin B1-glutathione and aflatoxin B1-cysteinylglycine were major thiol conjugates in rats and hamsters, respectively. An unknown metabolite believed to be mercapturic acid (N-acetylcysteine conjugate) of aflatoxin B1 was excreted by both species, hamster excreting twice as much as the rat. |
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Authors:
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H G Raj; P D Lotlikar |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer letters Volume: 22 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 1984 Mar |
Date Detail:
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Created Date: 1984-05-18 Completed Date: 1984-05-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 125-33 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcysteine
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urine Aflatoxin B1 Aflatoxins / isolation & purification, metabolism* Animals Carcinogens* Chromatography, High Pressure Liquid Cricetinae Dipeptides / urine Glutathione / urine Male Mesocricetus Rats Sulfhydryl Compounds / urine* |
| Grant Support | |
ID/Acronym/Agency:
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CA-12227/CA/NCI NIH HHS; CA-31641/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Aflatoxins; 0/Carcinogens; 0/Dipeptides; 0/Sulfhydryl Compounds; 1162-65-8/Aflatoxin B1; 19246-18-5/cysteinylglycine; 616-91-1/Acetylcysteine; 70-18-8/Glutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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