Document Detail

Urinary excretion of ten plasma proteins in patients with febrile diseases.
MedLine Citation:
PMID:  403746     Owner:  NLM     Status:  MEDLINE    
The 24-hour urinary excretion of albumin, transferrin, haptoglobin, IgG, IgA, IgM, free lambda and kappa light chains from immunoglobulin, lysozyme, and beta2-microglobulin has been investigated in 22 patients with febrile diseases, using an automated immunoprecipitin reaction. The average excretion of the 10 proteins was significantly increased in the patients compared with a control group. In patients with body temperature is greater than or equal to 38.5 degrees C the tubular type of proteinuria was significantly increased compared with those with body temperature is less than 38.5 degrees C. Sequential studies in 10 patients showed that the tubular type of proteinuria occurred in all, whereas the glomerular type was demonstrated in 8. when the fever had subsided, the tubular proteinuria disappeared rapidly i in all patients, while the glomerular proteinuria disappeared in only 4 out of 8. It was shown that tubular proteinuria was caused by fever per se, and it is suggested that glomerular prteinuria might be due to an immue response to antigens, derived from the infectious agents, producing a transient or permanent glomerular injury.
L Hemmingsen; P Skaarup
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Scandinavica     Volume:  201     ISSN:  0001-6101     ISO Abbreviation:  Acta Med Scand     Publication Date:  1977  
Date Detail:
Created Date:  1977-05-27     Completed Date:  1977-05-27     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370330     Medline TA:  Acta Med Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  359-64     Citation Subset:  AIM; IM    
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MeSH Terms
Fever / enzymology,  urine*
Haptoglobins / urine
Immunoglobulin A / urine
Immunoglobulin G / urine
Immunoglobulin Light Chains / urine
Immunoglobulin M / urine
Immunoglobulin kappa-Chains / urine
Immunoglobulin lambda-Chains / urine
Middle Aged
Muramidase / urine
Proteinuria / etiology*
Transferrin / urine
beta 2-Microglobulin / urine
Reg. No./Substance:
0/Haptoglobins; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin Light Chains; 0/Immunoglobulin M; 0/Immunoglobulin kappa-Chains; 0/Immunoglobulin lambda-Chains; 0/beta 2-Microglobulin; 11096-37-0/Transferrin; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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