Document Detail


Urinary excretion of polyamines by patients with advanced malignancy.
MedLine Citation:
PMID:  1222394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Levels of putrescrine, spermidine, and spermine in urine were determined by means of a sensitive ion-exchange chromatographic method in patients with advanced solid tumor malignancies, in patients with diseases other than cancer, and in normal control subjects. Elevation above 2 SDS of the normal mean were found in varying number of patients in each tumor category. For those malignancies studied that involved more than 20 patients, the greatest incidences of increased excretion were 66% for spermine in patients with colon carcinoma and 50% for putrescine and spermidine in patients with bronchogenic carcinoma. The highest levels and greatest frequency of elevated polyamine levels were found in patients with Burkitt's lymphoma, and changes in clinical tumor status associated with treatment appeared to correlate well with polyamine levels in this disease. Abnormal amounts of polyamines were also excreted by some patients with diseases other than cancer, indicating that increased polyamine excretion is not restricted or specific to the neoplastic state. It was also found that the levels of polyamines were apparently not affected by the intake of meat or the diet eaten, and remained in a rather narrow excretion range for any one individual at different time intervals. This study was carried out as part of a program to determine and evaluate biologic materials present in body fluids that may be used to follow and evaluate response or progression of neoplastic disease in patients during treatment regimens. The results suggest that abnormal urinary polyamine levels may be characteristic of neoplastic growth for some patients with malignant disease. Further studies are necessary to determine if these compounds may be helpful in assessing disease status for patients with such solid tumor malignancies as colon and bronchogenic carcinoma although their potential as useful "biologic markers" appears less promising than originally anticipated.
Authors:
T P Waalkes; C W Gehrke; D C Tormey; R W Zumwalt; J N Hueser; K C Kuo; D B Lakings; D L Ahmann; C G Moertel
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer chemotherapy reports. Part 1     Volume:  59     ISSN:  0069-0112     ISO Abbreviation:  Cancer Chemother Rep     Publication Date:    1975 Nov-Dec
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  7607105     Medline TA:  Cancer Chemother Rep     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1103-16     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Cadaverine / urine
Child
Chromatography, Ion Exchange
Female
Humans
Male
Neoplasm Metastasis
Neoplasms / urine*
Polyamines / urine*
Putrescine / urine
Sex Factors
Spermidine / urine
Spermine / urine
Chemical
Reg. No./Substance:
0/Polyamines; 110-60-1/Putrescine; 124-20-9/Spermidine; 462-94-2/Cadaverine; 71-44-3/Spermine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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