| Urinary excretion of olive oil phenols and their metabolites in humans. | |
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MedLine Citation:
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PMID: 11735087 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have recently demonstrated, in humans, the bioavailability of hydroxytyrosol (3,4-dihydroxyphenylethanol; HT), one of the major antioxidant components of virgin olive oil. In particular, we reported that this compound is present in lipoproteins involved in atherosclerotic processes and is excreted in the urine mainly as glucuronide-conjugate. The aim of the present study was to elucidate, in humans, the metabolic fate of HT after ingestion of virgin olive oil. After administration of virgin olive oil, 24-hour urine collections of healthy volunteers were prepared for gas chromatography-mass spectrometry analyses in order to identify and quantify HT and its metabolites homovanillic alcohol (HVA1c) and homovanillic acid (HVA). The results indicate that this compound undergoes the action of catechol-O-methyl transferase (COMT), enzymes involved in the catecholamine catabolism, resulting in an enhanced excretion of HVA1c. We also found a significant increase of HVA, indicating an oxidation of the ethanolic residue of HT and/or of HVA1c in humans. The excretion of both metabolites significantly correlated with the dose of administered HT. |
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Authors:
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D Caruso; F Visioli; R Patelli; C Galli; G Galli |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 50 ISSN: 0026-0495 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2001-12-05 Completed Date: 2002-01-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
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Languages: eng Pagination: 1426-8 Citation Subset: IM |
Copyright Information:
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Copyright 2001 by W.B. Saunders Company |
Affiliation:
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Department of Pharmacological Sciences, University of Milan, Milan, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Availability Catechol O-Methyltransferase / metabolism Gas Chromatography-Mass Spectrometry Homovanillic Acid / urine Humans Male Phenols / metabolism, pharmacokinetics, urine* Phenylethyl Alcohol / administration & dosage, analogs & derivatives*, metabolism, urine Plant Oils / administration & dosage*, chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Phenols; 0/Plant Oils; 10597-60-1/3,4-dihydroxyphenylethanol; 306-08-1/Homovanillic Acid; 60-12-8/Phenylethyl Alcohol; 8001-25-0/olive oil; EC 2.1.1.6/Catechol O-Methyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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