Document Detail

Urinary excretion of nitric oxide, cyclic GMP, and catecholamines during rest and activity period in transgenic hypertensive rats.
MedLine Citation:
PMID:  10373100     Owner:  NLM     Status:  MEDLINE    
Dysregulation of the system of nitric oxide (NO)-cyclic 3',5'-guanosine monophosphate (cGMP) might be involved in the development of hypertension in transgenic hypertensive TGR(mREN2)27 (TGR) rats. The present study was performed to determine possible differences in the day-night pattern and the urinary excretion rates of NO and cGMP in TGR rats in comparison to normotensive Sprague-Dawley (SPRD) controls. In addition, the urinary excretion of creatinine and catecholamines was measured in both rat strains. The day-night excretion patterns of NO, cGMP, catecholamines, and creatinine were preserved in TGR rats. Urinary excretion of NO was significantly decreased in TGR rats, whereas cGMP, the second messenger of NO, was elevated in the transgenic animals. Catecholamines and creatinine excretion rates did not differ between the strains. In conclusion, data suggest that a reduced NO synthesis could contribute to the increased blood pressure in the severely hypertensive rats. However, these data make it unlikely that the disturbances in the nitric oxide-cGMP system and the sympathetic nervous system are mainly responsible for the inverse circadian blood pressure rhythm in TGR rats.
S Globig; K Witte; B Lemmer
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chronobiology international     Volume:  16     ISSN:  0742-0528     ISO Abbreviation:  Chronobiol. Int.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-07-23     Completed Date:  1999-07-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8501362     Medline TA:  Chronobiol Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  305-14     Citation Subset:  IM    
Institut für Pharmakologie und Toxikologie, Fakultät für Klinische Medizin Mannheim, Ruprecht-Karls-Universität Heidelberg, Germany.
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MeSH Terms
Animals, Genetically Modified
Catecholamines / urine*
Chromatography, High Pressure Liquid
Circadian Rhythm / physiology*
Creatinine / urine
Cyclic GMP / urine*
Dopamine / urine
Epinephrine / urine
Hypertension / genetics,  physiopathology,  urine*
Nitric Oxide / urine*
Norepinephrine / urine
Rats, Sprague-Dawley
Reference Values
Renin / genetics*
Reg. No./Substance:
0/Catecholamines; 10102-43-9/Nitric Oxide; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 60-27-5/Creatinine; 7665-99-8/Cyclic GMP; EC

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