Document Detail


Urinary excretion of mutagens and the effects of sorbic acid on the lipid peroxide level in the mice fed on a 15% sorbic acid diet.
MedLine Citation:
PMID:  6663655     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The urine of the mice fed on a 15% sorbic acid diet was treated with or without beta-glucuronidase and was fractionated by XAD-2 column chromatography. The non-polar urine fraction was slightly mutagenic towards TA 98 when metabolically activated, but not towards TA 100. From the comparison of thin-layer chromatograms between the intestinal and urinary samples, it was suggested that a part of the mutagens produced in the intestine was excreted in the urine. As for the lipid peroxidation, the levels of lipid peroxide in the liver of the mice fed on a 15% sorbic acid diet were lower than those in the control over the feeding period of 15 months. Moreover, there was a correlation between the concentration of sorbic acid (X) in the diet and the lipid peroxide level (Y) in mice fed on potassium sorbate diets, obeying the linear equation, Y=-8.39X+ 341 (p less than 0.01). However, the lipid peroxide levels of 15% sorbic acid group did not fit with the above equation, and was higher than those of 20.1% potassium sorbate group, which was equivalent to 15% sorbic acid group in respect of sorbic acid concentration. Accordingly, the difference of lipid peroxide levels between the two groups (15% sorbic acid and 20.1% potassium sorbate group) might reflect productive difference of the mutagens.
Authors:
T Tsuchiya; T Yamaha
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of toxicological sciences     Volume:  8     ISSN:  0388-1350     ISO Abbreviation:  J Toxicol Sci     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1984-03-23     Completed Date:  1984-03-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7805798     Medline TA:  J Toxicol Sci     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  213-22     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Chromatography
Diet
Dose-Response Relationship, Drug
Fatty Acids, Unsaturated / administration & dosage*
Lipid Peroxides / metabolism*
Liver / metabolism
Mice
Mutagens / urine*
Sorbic Acid / administration & dosage*,  pharmacology
Time Factors
Chemical
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 0/Lipid Peroxides; 0/Mutagens; 110-44-1/Sorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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