| Urinary excretion of the main metabolites of methamphetamine, including p-hydroxymethamphetamine-sulfate and p-hydroxymethamphetamine-glucuronide, in humans and rats. | |
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MedLine Citation:
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PMID: 16702115 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The urinary concentrations of the main metabolites of methamphetamine (MA), specifically p-hydroxymethamphetamine-sulfate (p-OHMA-Sul) and p-hydroxymethamphetamine-glucuronide (p-OHMA-Glu), were directly measured in MA users and rats using an optimized LC-ESI MS method. The concentrations of the two conjugates in 50 MA human users' urine ranged from 0.09 to 88.6 microM (0.02-21.7 microg ml-1) for p-OHMA-Sul and from <0.05 to 7.13 microM (<0.02-2.43 microg ml-1) for p-OHMA-Glu; the ratios of sulfate to glucuronide (S/G ratios) ranged from 2.2 to 37.1 (13.8+/-8.1). The results demonstrate that the sulfation is quantitatively more important than glucuronidation for the conjugation of p-OHMA in humans. The urinary concentration time-dependency in two MA users also revealed that the conjugates were mostly excreted in urine within 3 days post-intake. In contrast, in rat, almost all of the conjugated p-OHMA (>99%) was excreted as the glucuronide in urine. These findings confirm that a large species variation exists in the conjugation of p-OHMA between humans and rats. |
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Authors:
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N Shima; H T Kamata; M Katagi; H Tsuchihashi |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Xenobiotica; the fate of foreign compounds in biological systems Volume: 36 ISSN: 0049-8254 ISO Abbreviation: Xenobiotica Publication Date: 2006 Feb-Mar |
Date Detail:
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Created Date: 2006-05-16 Completed Date: 2006-06-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1306665 Medline TA: Xenobiotica Country: England |
Other Details:
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Languages: eng Pagination: 259-67 Citation Subset: IM |
Affiliation:
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Forensic Science Laboratory, Osaka Prefectural Police Headquarters, Osaka, Japan. nori6499@amber.plala.or.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Glucuronides / urine* Humans Male Metabolic Clearance Rate Methamphetamine / administration & dosage*, analogs & derivatives*, urine* Rats Rats, Wistar Species Specificity Sulfates / urine |
| Chemical | |
Reg. No./Substance:
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0/Glucuronides; 0/Sulfates; 370-14-9/pholedrine; 537-46-2/Methamphetamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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