Document Detail

Urinary excretion of cyanidin glycosides.
MedLine Citation:
PMID:  12406587     Owner:  NLM     Status:  MEDLINE    
Anthocyanins, which are natural plant pigments from the flavonoid family, represent substantial constituents of the human diet. Several fruits (blackcurrant, blue berries, red grape and elderberry) are rich sources of these efficient antioxidant compounds. The present study was designed to determine the potential bioavailability in humans of the anthocyanins of elderberry, mainly cyanidin-3-glucoside and cyanidin-3-sambubioside, and the influence of the simultaneous ingestion of sucrose on the absorption of anthocyanins. Urinary samples from 16 healthy volunteers--8 women and 8 men--were collected before and over a period of 6 h with intervals of 1 h after the ingestion of 11 g elderberry concentrate (containing 1.9 g of anthocyanins equivalent to 235 ml of fresh juice) 1 day diluted with water, the other day with 30 g sucrose. Using high-performance liquid chromatography, it was possible to quantify the two main anthocyanins of elderberry excreted unchanged in the urine (0.003-0.012% of the oral dose). The ingestion of sucrose led to a reduced excretion of anthocyanins.
Ursula Mülleder; Michael Murkovic; Werner Pfannhauser
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biochemical and biophysical methods     Volume:  53     ISSN:  0165-022X     ISO Abbreviation:  J. Biochem. Biophys. Methods     Publication Date:    2002 Oct-Nov
Date Detail:
Created Date:  2002-10-30     Completed Date:  2003-09-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7907378     Medline TA:  J Biochem Biophys Methods     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  61-6     Citation Subset:  IM    
Department of Food Chemistry and Technology, Graz University of Technology, Petersgasse 12/2, 8010 Graz, Austria.
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MeSH Terms
Administration, Oral
Anthocyanins / administration & dosage,  analysis,  metabolism*,  urine*
Antioxidants / administration & dosage,  analysis,  metabolism
Biological Availability
Chromatography, High Pressure Liquid / methods
Cross-Over Studies
Fruit / chemistry,  metabolism
Mass Spectrometry / methods
Sambucus / chemistry*,  metabolism*
Sucrose / administration & dosage,  metabolism
Reg. No./Substance:
0/Anthocyanins; 0/Antioxidants; 57-50-1/Sucrose

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