Document Detail

Urinary excretion of conjugated homovanillic acid, 3,4-dihydroxyphenylacetic acid, p-hydroxyphenylacetic acid, and vanillic acid by persons on their usual diet and patients with neuroblastoma.
MedLine Citation:
PMID:  455649     Owner:  NLM     Status:  MEDLINE    
We report quantitative data on beta-glucuronidase- and sulfatase-hydrolyzable conjugates of homovanillic acid, 3,4-dihydroxyphenylacetic acid, p-hydroxyphenylacetic acid, and vanillic acid in the urine of 20 apparently normal and healthy control persons and of three patients with neuroblastoma. We used organic solvent extraction and capillary gas chromatography. There was considerable person-to-person variation in the conjugation percentages calculated. Mean conjugated percentages of the four compounds for 16 normal healthy persons 2.5--40 years of age were, respectively, 12%, 33%, 14%, and 35%. For newborns and patients with neuroblastoma, these percentages were somewhat different. Increased amounts of vanillic acid were found in the urine of the patients with neuroblastoma, but results of a small metabolic study in rats suggest that this increase most probably is of dietary origin.
F A Muskiet; A Groen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical chemistry     Volume:  25     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1979 Jul 
Date Detail:
Created Date:  1979-09-17     Completed Date:  1979-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1281-4     Citation Subset:  IM    
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / urine*
Child, Preschool
Homovanillic Acid / urine*
Hydroxybenzoic Acids / urine*
Infant, Newborn
Neuroblastoma / urine*
Phenylacetates / urine*
Vanillic Acid / urine*
Reg. No./Substance:
0/Hydroxybenzoic Acids; 0/Phenylacetates; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 121-34-6/Vanillic Acid; 306-08-1/Homovanillic Acid; EC 3.1.6.-/Sulfatases; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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