Document Detail


Urinary excretion of conjugated homovanillic acid, 3,4-dihydroxyphenylacetic acid, p-hydroxyphenylacetic acid, and vanillic acid by persons on their usual diet and patients with neuroblastoma.
MedLine Citation:
PMID:  455649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report quantitative data on beta-glucuronidase- and sulfatase-hydrolyzable conjugates of homovanillic acid, 3,4-dihydroxyphenylacetic acid, p-hydroxyphenylacetic acid, and vanillic acid in the urine of 20 apparently normal and healthy control persons and of three patients with neuroblastoma. We used organic solvent extraction and capillary gas chromatography. There was considerable person-to-person variation in the conjugation percentages calculated. Mean conjugated percentages of the four compounds for 16 normal healthy persons 2.5--40 years of age were, respectively, 12%, 33%, 14%, and 35%. For newborns and patients with neuroblastoma, these percentages were somewhat different. Increased amounts of vanillic acid were found in the urine of the patients with neuroblastoma, but results of a small metabolic study in rats suggest that this increase most probably is of dietary origin.
Authors:
F A Muskiet; A Groen
Related Documents :
16104789 - Identification of rat urinary and fecal metabolites of a new herbicide, pyribenzoxim.
3411439 - Metabolism of diltiazem. i. structures of new acidic and basic metabolites in rat, dog ...
25107579 - Erythrocyte very long-chain saturated fatty acids associated with lower risk of inciden...
9090069 - Thiodiacetic acid--a metabolite of ethylene oxide.
41039 - The effects of physiocochemical properties of pethidine and its basic metabolites on th...
22423959 - Investigation of the differences in thermal stability of two recombinant human serum al...
22950419 - Effect of different postharvest temperatures on the accumulation of sugars, organic aci...
15099439 - Absorption of taurocholic acid by the ileum of normal and transgenic deltaf508 cystic f...
4026899 - Synthesis and antimicrobial activity of some benzofuran derivatives.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical chemistry     Volume:  25     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1979 Jul 
Date Detail:
Created Date:  1979-09-17     Completed Date:  1979-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1281-4     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
3,4-Dihydroxyphenylacetic Acid / urine*
Adult
Animals
Child
Child, Preschool
Glucuronidase
Homovanillic Acid / urine*
Humans
Hydroxybenzoic Acids / urine*
Infant
Infant, Newborn
Male
Neuroblastoma / urine*
Phenylacetates / urine*
Rats
Sulfatases
Vanillic Acid / urine*
Chemical
Reg. No./Substance:
0/Hydroxybenzoic Acids; 0/Phenylacetates; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 121-34-6/Vanillic Acid; 306-08-1/Homovanillic Acid; EC 3.1.6.-/Sulfatases; EC 3.2.1.31/Glucuronidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Creatine kinase B-subunit activity in serum after immunoinhibition of M-subunit activity.
Next Document:  Comparison of acid phosphatase isoenzymes of human seminal fluid, prostate, and leukocytes.