Document Detail

Urinary excretion of adrenocortical steroid metabolites by pre-term human infants: trends from birth until 3 months post term.
MedLine Citation:
PMID:  8969936     Owner:  NLM     Status:  MEDLINE    
We report trends in urinary steroid excretion in serial 24 hour collections made using a novel method based on "Supersorb" type disposable nappies. Using capillary column gas chromatography, we quantified nine cortisol metabolites (FM) and 11 steroid sulphates (SM) in 6 infants born at 29-31 weeks gestation on 9 occasions until 24 weeks post delivery. In all infants, SM excretion increased progressively until 33-39 weeks (mean 36.8) post conception to maxima of (all values mg/24 h) 2.6-11.7 and then declined to 5-15% of peak values at the end of the study period in 4 infants born after a period of labour but to only 54 and 71% in 2 infants born without labour. FM levels showed a wide range which was not correlated with body weight, eg: on week 1, 0.06-0.20 and on week 24, 0.15-0.72. progression over this period was essentially linear. The ratio (mean (SD)) of 11-oxo/11-hydroxy metabolites decreased from 10.0 (8.2) to 2.3 (0.4) in the same period, p = < 0.10, while that of 20-oxo/20-hydroxy metabolites increased from 0.18 (0.07) to 1.08 (0.42), p = < 0.04. The ratio of metabolites with 5 oxygen functions relative to 6 increased from 0.38 (0.16) to 1.36 (0.43), p = < 0.04. Excretion of 5 alpha-tetrahydrocortisol began to rise at 44-47 wk post conception, but, unexpectedly, that of the 5 beta epimer began to rise sooner, at 39-41 wk, reaching a peak at 44-51 wk and then declining. The ratio of 5 beta/5 alpha epimers was 11.71 (11.1) at the peak and 1.14 (0.87) at 24 weeks, p = < 0.07. We conclude that, using a collection method which is reliable, non-stressful and repeatable at frequent intervals, new information on the evolution of steroid secretion and metabolism postpartum is emerging.
N Taylor; S Sharma; F Giffin; S Naik; A Greenough
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endocrine research     Volume:  22     ISSN:  0743-5800     ISO Abbreviation:  Endocr. Res.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-03-13     Completed Date:  1997-03-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8408548     Medline TA:  Endocr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  741-9     Citation Subset:  IM    
Department of Clinical Chemistry, King's College School of Medicine, London, UK.
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MeSH Terms
Adrenal Cortex Hormones / urine*
Chromatography, Gas
Gestational Age
Hydrocortisone / urine
Infant, Newborn
Infant, Premature / urine*
Labor, Obstetric / physiology
Sulfates / urine
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Sulfates; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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