| Urinary excretion of 5-L-oxoproline (pyroglutamic acid) is increased in normal adults consuming vegetarian or low protein diets. | |
| | |
MedLine Citation:
|
PMID: 8914953 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A method for measuring 5-L-oxoproline in urine, which involves isolation by short-column chromatography, acid hydrolysis to glutamic acid and enzymic assay of glutamic acid, was used to measure the rate of excretion in normal adults, aged 20 to 45 y. There was no difference in the daily excretion between omnivorous males (217 micromol/d) and females (195 micromol/d). In vegetarian males, urinary 5-L-oxoproline (404 micromol/d) was significantly greater than in vegetarian females (267 micromol/d, P = 0.013). Compared with omnivorous males or females, excretion of 5-L-oxoproline was significantly greater in vegetarian males (P < 0.0001) and females (P= 0.005). When normal adults consumed a diet in which the protein content was controlled at either 4.0 or 6.2 g N/d for 5 d, there was a significant increase in urinary 5-L-oxoproline on d 5, compared with either d 1 or 4. There was a significant inverse linear relationship between the increased urinary 5-L-oxoproline on the fifth dietary day and the nitrogen content of the diet. On the basis of this relationship, when the urinary excretion of 5-L-oxoproline (320 micromol/d) for vegetarians was predicted from an estimate of their dietary intake of nitrogen, the estimate was, on average, close to the measured value (345 micromol/d). As a matter of course, vegetarians excrete more 5-L-oxoproline in urine than do omnivores, and we speculated that this difference might be accounted for by differences in dietary nitrogen and the endogenous capacity for de novo synthesis of glycine. |
| | |
Authors:
|
A A Jackson; C Persaud; T S Meakins; R Bundy |
Related Documents
:
|
7942583 - Alginate, small bowel sterol excretion, and absorption of nutrients in ileostomy subjects. 414463 - The metabolism of ftorafur in the beagle dog and rhesus monkey. 16785043 - Screening the antioxidant and antimicrobial properties of the lichens parmelia saxatili... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of nutrition Volume: 126 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 1996 Nov |
Date Detail:
|
Created Date: 1997-01-13 Completed Date: 1997-01-13 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 2813-22 Citation Subset: IM |
Affiliation:
|
Institute of Human Nutrition, University of Southampton, United Kingdom. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aging / metabolism Analysis of Variance Body Height / physiology Body Mass Index Body Weight / physiology Circadian Rhythm / physiology Diet, Protein-Restricted* Diet, Vegetarian* Female Glutamic Acid / analysis Humans Male Middle Aged Nitrogen / metabolism Pyrrolidonecarboxylic Acid / urine* Time Factors |
| Chemical | |
Reg. No./Substance:
|
56-86-0/Glutamic Acid; 7727-37-9/Nitrogen; 98-79-3/Pyrrolidonecarboxylic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prediction of glucose and insulin responses of normal subjects after consuming mixed meals varying i...
Next Document: Urinary excretion of 5-L-oxoproline (pyroglutamic acid) is increased during recovery from severe chi...