Document Detail

Urinary endothelin-1-like immunoreactivity excretion in the newborn period.
MedLine Citation:
PMID:  8517899     Owner:  NLM     Status:  MEDLINE    
Urinary endothelin-1-like immunoreactivity (ET-1-LI) excretion was determined in 31 neonates, six sick infants with renal dysfunction secondary to neonatal asphyxia and 25 healthy infants, during the first week of life to clarify its evolutional change and the origin of the urinary ET-1-LI in the newborn period. Urinary ET-1-LI concentrations in the healthy infants maintained the same level during the first week of life (n = 35, 36 +/- 22 pg/mg creatinine, mean +/- SD). There was no difference in urinary ET-1-LI excretion in infants between 30 and 41 weeks of gestation. Urinary ET-1-LI concentrations in the sick infants were significantly elevated through the first week of life when compared with those of healthy infants. Fractional excretion of sodium and endothelin clearance were more elevated in the sick infants than in the healthy infants. A good correlation was observed between urinary ET-1-LI concentrations and urinary N-acetyl-beta-D-glucosaminidase index (r = 0.72, p < 0.01). These results suggest that the origin of urinary endothelin-1 may be the renal tissue and that ET-1 may be a nonspecific marker of renal injury in neonates.
T Kojima; Y Isozaki-Fukuda; M Sasai; Y Hirata; S Matsuzaki; Y Kobayashi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of perinatology     Volume:  10     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-07-29     Completed Date:  1993-07-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  220-3     Citation Subset:  IM    
Department of Pediatrics, Kansai Medical University, Osaka, Japan.
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MeSH Terms
Acetylglucosaminidase / urine
Asphyxia Neonatorum / urine*
Biological Markers / urine
Endothelins / urine*
Gestational Age
Infant, Newborn / urine*
Kidney / metabolism
Reg. No./Substance:
0/Biological Markers; 0/Endothelins; EC

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