Document Detail

Urinary dopamine and noradrenaline outputs during oral salt loading in healthy Chinese subjects with a family history of hypertension.
MedLine Citation:
PMID:  8736424     Owner:  NLM     Status:  MEDLINE    
1. Increased salt sensitivity has been reported in first-degree relatives of hypertensive patients. To determine if the enhanced effect of oral salt intake on blood pressure in such individuals is related to abnormal renal dopamine (DA) or sympathetic nervous system responses, we studied the effects of two different sodium intakes (20 mmol/day followed by 220 mmol/day each given for 5 days) on mean arterial pressure (MAP) and urinary excretion of sodium, free DA and noradrenaline (NA) in seven normotensive Chinese subjects with a family history of hypertension. We compared these results with those we have reported previously for normotensive subjects without a family history of hypertension. 2. There was a seven- to ten-fold increase in sodium excretion (P < 0.02). MAP increased from 80.1 +/- 2.5 to 83.1 +/- 2.1 mmHg (P < 0.05). A 23% increase in urine DA (P < 0.02) was seen on day 1. From day 2 to day 5, the increase in urine DA (12-15%) became attenuated and reached statistical significance only on days 2 and 5. There was no significant change in urinary NA output. 3. As in healthy Chinese subjects without a family history of hypertension, those with a family history showed an early but unsustained rise in urine DA during oral sodium loading. Such an increase was rather small compared to the increase in urine sodium, suggesting that renal DA only contributes partly to the natriuretic response. Unlike those with no family history, subjects with a family history showed an increase in blood pressure after oral salt loading, possibly because of inadequate suppression of sympathetic nervous system activity.
T Y Chan; J A Critchley; C S Ho; J C Chan; B Tomlinson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of autonomic pharmacology     Volume:  16     ISSN:  0144-1795     ISO Abbreviation:  J Auton Pharmacol     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-10-24     Completed Date:  1996-10-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8106455     Medline TA:  J Auton Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
Department of Clinical Pharmacology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin.
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MeSH Terms
Asian Continental Ancestry Group
Blood Pressure
Dopamine / urine*
Family Health*
Norepinephrine / urine*
Potassium / urine
Sodium / urine
Sodium, Dietary / administration & dosage*
Reg. No./Substance:
0/Sodium, Dietary; 51-41-2/Norepinephrine; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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