Document Detail


Urinary desmosine excretion in acute exacerbations of COPD: a preliminary report.
MedLine Citation:
PMID:  11860167     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Desmosine (DES) is an elastin-derived, cross-link amino acid, which is not metabolized; hence, its urinary levels reflect elastin breakdown. We hypothesized that elastin degradation should increase as a result of increased lung inflammation during an acute exacerbation of COPD and should decrease after recovery. To test this hypothesis we measured DES in three urine samples from nine COPD subjects during the first 5 days of an acute exacerbation and at 2 months after recovery. We also measured forced expiratory volume in 1 sec (FEV1) to monitor the effects ofthe exacerbation on ventilatory function. The mean (SD) FEV1 was 45 (15)% predicted during the exacerbation and 57.8 (16)% predicted 2 months later (P=0.00001). The mean (SD) DES excretion was 25.3 (9) microg g(-1) creatinine at day 1;23.5 (9) at day 3 and 24 (9) at day 5 of the exacerbation. The mean (SD) urinary DES excretion 60 days after discharge was 20.9 (7) microg g(-1) creatinine (P=0.049) in comparison with the mean of the three acute-phase values. The size of the increase in desmosine excretion during exacerbation is small, 3.2 microg g(-1) creatinine or 16% of the recovery desmosine value. We conclude that there is a small but statistically significant increase in lung elastin breakdown in the body during an acute exacerbation of COPD.
Authors:
D Fiorenza; S Viglio; A Lupi; J Baccheschi; C Tinelli; R Trisolini; R Iadarola; M Luisetti; G L Snider
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiratory medicine     Volume:  96     ISSN:  0954-6111     ISO Abbreviation:  Respir Med     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-25     Completed Date:  2002-03-13     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  110-4     Citation Subset:  IM    
Affiliation:
Laboratorio di Biochimica e Genetica della Clinica di Malattie dell'Apparato Respiratorio, IRCCS Policlinico San Matteo, Universita degli Studi di Pavia, Italy.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Aged
Analysis of Variance
Biological Markers / urine
Chromatography, Micellar Electrokinetic Capillary
Desmosine / urine*
Elastin / urine*
Forced Expiratory Volume
Humans
Longitudinal Studies
Male
Middle Aged
Pulmonary Disease, Chronic Obstructive / physiopathology,  urine*
Chemical
Reg. No./Substance:
0/Biological Markers; 11003-57-9/Desmosine; 9007-58-3/Elastin

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