Document Detail


Urinary desmosine as a biomarker in acute lung injury.
MedLine Citation:
PMID:  16484139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute lung injury (ALI) is a complex disorder associated with an acute inflammatory response thought to contribute to tissue injury. Desmosine, a cross-linking amino acid present in elastin, is released during matrix degradation and cleared by the kidney. Results from animal models and human disease studies have suggested that ALI is associated with the release of desmosine, resulting in increased urinary desmosine. A radioimmunoassay was used to monitor urinary desmosine levels over 10 days in ten patients with ALI. The concentration of desmosine was measured with and without acid hydrolysis. Baseline urinary desmosine was increased in two of ten patients. The concentration of desmosine at baseline did not appear to be related to age, gender, neutrophil elastase (NE)/alpha(1)-antiprotease complex concentration or P(a)O(2)/F(i)O(2) ratio. No meaningful changes in desmosine levels were noted after removal from mechanical ventilation. Baseline desmosine concentrations did not appear to correlate with the risk of death. The limited sensitivity, predictive correlations and dynamic modulation would suggest that urine desmosine has a limited role as a biomarker for ALI. Hydrolysis of urine samples appears necessary for optimal measurement of urine desmosine.
Authors:
J A Fill; J T Brandt; H P Wiedemann; B L Rinehart; C F Lindemann; J J Komara; R R Bowsher; M C Spence; B G Zeiher
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Publication Detail:
Type:  Journal Article; Validation Studies    
Journal Detail:
Title:  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals     Volume:  11     ISSN:  1354-750X     ISO Abbreviation:  Biomarkers     Publication Date:    2006 Jan-Feb
Date Detail:
Created Date:  2006-02-17     Completed Date:  2006-08-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606000     Medline TA:  Biomarkers     Country:  England    
Other Details:
Languages:  eng     Pagination:  85-96     Citation Subset:  IM    
Affiliation:
Eli Lilly and Co, Lilly Corporate Center, Indianapolis, IN 46285, USA. jfill@lilly.com
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Biological Markers / urine*
Desmosine / urine*
Female
Humans
Male
Middle Aged
Radioimmunoassay
Reference Standards
Reproducibility of Results
Chemical
Reg. No./Substance:
0/Biological Markers; 11003-57-9/Desmosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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