Document Detail

Urinary cyclic GMP, endothelin, and prostaglandin E2 in normal pregnancy and preeclampsia.
MedLine Citation:
PMID:  9394167     Owner:  NLM     Status:  MEDLINE    
Cyclic GMP, endothelin and prostaglandin E2 (PGE2) all have systemic vasoactive properties (with cyclic GMP acting as a second messenger of nitric oxide). Intrarenally they act as natriuretics and urinary levels reflect intrarenal production. Cyclic GMP and PGE2 also act as important inhibitors of platelet activation and thrombosis. The purpose of this study was to determine if urinary levels of cyclic GMP, endothelin, and PGE2 differ in preeclamptic as compared to normal pregnancies. Parameters were compared in 13 normotensive, nonpreeclamptic pregnancies, and 32 preeclamptic pregnancies. Preeclamptic women had significantly lower levels of urinary cyclic GMP (0.67 +/- 0.12 vs. 2.1 +/- 0.5 nmol/g creatinine), endothelin (0.88 +/- 0.09 vs. 3.75 +/- 1.4 ng/g creatinine), and PGE2 (26 +/- 4 vs. 9 ng/g creatinine) as compared to normals (p < 0.05). Intrarenal production of cyclic GMP, endothelin, and PGE2 are all disturbed in preeclampsia and may have implications in the sodium retention, hypertension, and intrarenal thrombosis and vasospasm of preeclamptic pregnancy.
B A Clark; J Ludmir; F H Epstein; J Alvarez; L Tavara; J Bazul; A Franco; E Maradiegue; A Ludmir
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of perinatology     Volume:  14     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1998-02-10     Completed Date:  1998-02-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  559-62     Citation Subset:  IM    
Department of Medicine, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts, USA.
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MeSH Terms
Blood Pressure
Cyclic GMP / urine*
Dinoprostone / urine*
Endothelins / urine*
Pre-Eclampsia / blood,  physiopathology,  urine*
Pregnancy / blood,  physiology,  urine*
Pregnancy Outcome
Reg. No./Substance:
0/Endothelins; 363-24-6/Dinoprostone; 7665-99-8/Cyclic GMP

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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