| Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol a. | |
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MedLine Citation:
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PMID: 22267036 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Bisphenol A (BPA) is one of the highest-volume chemicals produced worldwide, and human exposure to BPA is thought to be ubiquitous. Thus, there are concerns that the amount of BPA to which humans are exposed may cause adverse health effects. We examined many possibilities for why biomonitoring and toxicokinetic studies could come to seemingly conflicting conclusions. More than 80 published human biomonitoring studies that measured BPA concentrations in human tissues, urine, blood, and other fluids, along with two toxicokinetic studies of human BPA metabolism were examined. Unconjugated BPA was routinely detected in blood (in the nanograms per milliliter range), and conjugated BPA was routinely detected in the vast majority of urine samples (also in the nanograms per milliliter range). In stark contrast, toxicokinetic studies proposed that humans are not internally exposed to BPA. Available data from biomonitoring studies clearly indicate that the general population is exposed to BPA and is at risk from internal exposure to unconjugated BPA. The two toxicokinetic studies that suggested human BPA exposure is negligible have significant deficiencies, are directly contradicted by hypothesis-driven studies, and are therefore not reliable for risk assessment purposes. |
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Authors:
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Laura N Vandenberg; Ibrahim Chahoud; Jerrold J Heindel; Vasantha Padmanabhan; Francisco J R Paumgartten; Gilbert Schoenfelder |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Ciência & saúde coletiva Volume: 17 ISSN: 1678-4561 ISO Abbreviation: Cien Saude Colet Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9713483 Medline TA: Cien Saude Colet Country: Brazil |
Other Details:
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Languages: eng Pagination: 407-34 Citation Subset: IM |
Affiliation:
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Department of Biology, Tufts University, Medford, MA, USA, 02155, laura.vandenberg@tufts.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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