Document Detail

Urinary catecholamines, plasma renin activity and blood pressure in newborns: effects of narcotic withdrawal.
MedLine Citation:
PMID:  6274596     Owner:  NLM     Status:  MEDLINE    
Blood pressure and plasma renin activity were studied in 13 infants of drug-dependent mothers (heroin and/or methadone) and 20 control newborns for a period of 21 days. Urinary excretion of epinephrine and norepinephrine were also measured at 24 and 48 h of age. The systolic blood pressure was found to be significantly elevated in newborns of drug-dependent mothers compared with controls (p less than 0.01), but diastolic blood pressure levels were similar. Plasma renin activity was significantly elevated (p less than 0.001) at 48-72 h and urinary epinephrine levels were significantly lower (p less than 0.05) at 24-48 h of age in the drug group, and norepinephrine levels were equivalent. Systolic hypertension and elevated plasma renin activity in these newborns of dependent mothers may be due to increased beta-adrenergic receptor sensitivity.
S K Dube; R C Jhaveri; W Rosenfeld; H E Evans; F Khan; G Spergel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developmental pharmacology and therapeutics     Volume:  3     ISSN:  0379-8305     ISO Abbreviation:  Dev Pharmacol Ther     Publication Date:  1981  
Date Detail:
Created Date:  1982-03-13     Completed Date:  1982-03-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8003947     Medline TA:  Dev Pharmacol Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  83-7     Citation Subset:  IM    
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MeSH Terms
Catecholamines / urine*
Heroin / adverse effects*
Hypertension / etiology*
Infant, Newborn
Infant, Newborn, Diseases / chemically induced*,  physiopathology
Methadone / adverse effects*
Receptors, Adrenergic, beta / metabolism
Renin / blood*
Substance Withdrawal Syndrome / etiology*
Reg. No./Substance:
0/Catecholamines; 0/Receptors, Adrenergic, beta; 561-27-3/Heroin; 76-99-3/Methadone; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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