Document Detail


Urinary catabolites of ribonucleic acid as cancer markers: a preliminary report of their use in patients with lung cancer.
MedLine Citation:
PMID:  6087748     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rats with aflatoxin-B1-induced hepatomas and dimethylnitrosamine-induced nephroblastomas excreted greater than normal amounts of urinary modified nucleosides and bases, catabolites of ribonucleic acid (RNA). Although both neoplasms caused increased excretions of the same catabolites, their quantitative profiles differed, suggesting that it may be possible to distinguish between tumors. Rats with transplanted tumors (e.g., hepatomas and osteogenic sarcomas) did not excrete elevated levels of urinary RNA catabolites until approximately 20 days after transplantation despite rapid growth of the tumor for the first 15 days. These data suggest that the source of the elevated levels of these excretory products may be the host's tissue RNA. Preliminary studies in human beings with lung cancer showed marked elevation of one or more urinary RNA catabolites. Resection of the diseased tissue in 2 patients caused a drop in levels. The measurement of urinary RNA catabolites may be useful in the diagnosis, prognosis, and evaluation of therapy in patients with lung cancer.
Authors:
J W Mackenzie; R J Lewis; G E Sisler; W Lin; J Rogers; I Clark
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  38     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-09-04     Completed Date:  1984-09-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  133-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aflatoxin B1
Aflatoxins
Animals
Dimethylnitrosamine
Female
Humans
Liver Neoplasms, Experimental / chemically induced,  urine
Lung Neoplasms / surgery,  urine*
Male
Neoplasm Transplantation
Nucleosides / urine*
Osteosarcoma / urine
RNA, Neoplasm / urine*
Rats
Rats, Inbred ACI
Rats, Inbred Strains
Wilms Tumor / chemically induced,  urine
Chemical
Reg. No./Substance:
0/Aflatoxins; 0/Nucleosides; 0/RNA, Neoplasm; 1162-65-8/Aflatoxin B1; 62-75-9/Dimethylnitrosamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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