| Urinary calcium and magnesium excretion relates to increase in blood pressure during pregnancy. | |
| | |
MedLine Citation:
|
PMID: 20135136 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: Pregnancy-induced hypertension and preeclampsia are serious clinical manifestations during late pregnancy and the cause for increased maternal and foetal morbidity and mortality. The pathogenesis is unknown but experience from treatment schemes suggests that minerals may be of importance. Mineral homeostasis is influenced by acid-base conditions. The aim of the study was to elucidate the relation between acid-base balance, urinary mineral excretion and blood pressure during pregnancy. DESIGN: A prospective observational study of a general population. MATERIALS AND METHODS: The study was performed at the Midwife Health Center in Borås, Sweden, where practically all pregnant subjects in the catchment area are registered. First time pregnant subjects (n = 123) were voluntarily recruited without exclusion criteria. A 24 h urine sample was collected at pregnancy week 12 and analyzed for creatinine, calcium, magnesium, and urea as a proxy for acid conditions. Blood pressure was recorded every 2-3 weeks until delivery. RESULTS: There was a relation between the excretion of urea and calcium and magnesium at week 12. A blood pressure increase was found after pregnancy week 30 but only among subjects who had a high excretion of calcium and magnesium at week 12. CONCLUSIONS: If an increase in blood pressure during the later part of pregnancy a risk indicator for preeclampsia, the results suggest that an excessive secretion of calcium leading to a functional deficit might be a risk indicator for gestational hypertension and preeclampsia. Intervention experiments are required to assess this hypothesis. |
| | |
Authors:
|
Thorkild F Nielsen; Ragnar Rylander |
Related Documents
:
|
1961116 - Leucine kinetics and fuel utilization during a brief fast in human pregnancy. 1090436 - Cortisol metabolism in the baboon during pregnancy and the postpartum period. 3099016 - Successful pregnancy outcome using total parenteral nutrition from the first trimester ... 11427036 - The effect of revascularisation of an ischaemic lower limb on leukotriene e4 production. 11944996 - Immune regulation during pregnancy and host-pathogen interactions in infectious abortion. 20464586 - Non-pharmacological management of migraine during pregnancy. |
Publication Detail:
|
Type: Journal Article Date: 2010-02-05 |
Journal Detail:
|
Title: Archives of gynecology and obstetrics Volume: 283 ISSN: 1432-0711 ISO Abbreviation: Arch. Gynecol. Obstet. Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-02-09 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8710213 Medline TA: Arch Gynecol Obstet Country: Germany |
Other Details:
|
Languages: eng Pagination: 443-7 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Hjorring Central Hospital, Hjorring, Denmark. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinicopathological and immunohistochemical analysis of sclerosing stromal tumours of the ovary.
Next Document: Sexual experience and risky sexual behaviours of Turkish university students.