Document Detail


Urinary cGMP concentrations in severe primary pulmonary hypertension.
MedLine Citation:
PMID:  10195079     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Prognostic evaluation of patients with primary pulmonary hypertension (PPH) requires right heart catheterisation. The development of accurate non-invasive methods for monitoring these patients remains an important task. Cyclic guanosine monophosphate (cGMP) is an indicator of the action of natriuretic peptides and nitric oxide on target cells. Plasma and urinary cGMP concentrations are raised in patients with congestive heart failure in whom they correlate closely with haemodynamic parameters and disease severity. The aim of the present study was to determine whether the urinary concentration of cGMP could be used as a non-invasive marker of haemodynamic impairment in patients with severe PPH. METHODS: Urinary cGMP concentrations were measured in 19 consecutive patients with PPH, seven with acute asthma, and 30 normal healthy controls. RESULTS: Patients with PPH had higher urinary cGMP concentrations than asthmatic patients or normal healthy controls (p = 0.001). Urinary cGMP concentrations were higher in patients with severe haemodynamic impairment--that is, those with a cardiac index (CI) of < or = 2 l/min/m2 (p = 0.002)--and urinary cGMP concentrations were inversely correlated with CI (r = -0.69, p = 0.002) and venous oxygen saturation (r = -0.65, p = 0.003). CONCLUSION: Urinary cGMP concentrations may represent a non-invasive indicator of the haemodynamic status of patients with severe PPH.
Authors:
M Bogdan; M Humbert; J Francoual; C Claise; P Duroux; G Simonneau; A Lindenbaum
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thorax     Volume:  53     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-04-19     Completed Date:  1999-04-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1059-62     Citation Subset:  IM    
Affiliation:
Service de Pneumologie, UPRES Maladie Vasculaires Pulmonaires, Hôpital Antoine Béclère, Clamart, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Asthma / urine
Biological Markers / urine
Cardiac Output
Cyclic GMP / urine*
Female
Heart Catheterization
Hemodynamics
Humans
Hypertension, Pulmonary / physiopathology,  urine*
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Biological Markers; 7665-99-8/Cyclic GMP
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