Document Detail

Urinary cGMP as biological marker of the renal activity of atrial natriuretic factor.
MedLine Citation:
PMID:  2849318     Owner:  NLM     Status:  MEDLINE    
Current evidence suggests guanosine 3',5'-cyclic monophosphate (cGMP) serves as the second messenger for atrial natriuretic factor (ANF) in the kidney in vivo. We examined whether extracellular cGMP accumulation quantitatively reflected the concentration of cGMP within renal cells and whether urinary excretion of cGMP correlated with the physiological action of ANF. cGMP egression was examined in renal epithelial LLC-PK1 cells. ANF augmented intracellular cGMP concentration and extracellular cGMP appearance. Extracellular cGMP was an excellent function of the time-integrated intracellular cGMP concentration. In clearance studies in awake rats, urinary cGMP was primarily of renal cellular origin and correlated with the natriuresis induced by ANF in a time-dependent and concentration-dependent fashion. Urinary cGMP excretion may be useful as a biological marker for the renal activity of ANF in vivo.
K R Wong; M H Xie; L B Shi; F Y Liu; C L Huang; D G Gardner; M G Cogan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  255     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-01-26     Completed Date:  1989-01-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  F1220-4     Citation Subset:  IM    
Department of Medicine, University of California, San Francisco 94143.
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MeSH Terms
Atrial Natriuretic Factor / pharmacology*
Biological Markers / urine*
Cell Line
Cyclic GMP / secretion,  urine*
Kidney / drug effects,  physiology*
Rats, Inbred Strains
Reference Values
Second Messenger Systems*
Sodium / urine
Grant Support
Reg. No./Substance:
0/Biological Markers; 7440-23-5/Sodium; 7665-99-8/Cyclic GMP; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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