Document Detail


Urinary bladder urothelium: molecular sensors of chemical/thermal/mechanical stimuli.
MedLine Citation:
PMID:  16891158     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The identification of functional receptors/ion channels in bladder urothelial cells and the involvement of these sensor molecules in the release of chemical mediators (nitric oxide, NO; ATP) suggest that urothelial cells exhibit specialized sensory and signaling properties. Such mechanisms could allow these cells to respond to their chemical and physical environments and to engage in reciprocal communication with neighboring urothelial cells as well as nerves in the bladder wall. These and other findings highlight the functional importance of the urinary bladder urothelium and suggest that perturbations in urothelial targets and/or cell-cell interactions may lead to a number of urinary tract abnormalities.
Authors:
Lori A Birder
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2006-06-29
Journal Detail:
Title:  Vascular pharmacology     Volume:  45     ISSN:  1537-1891     ISO Abbreviation:  Vascul. Pharmacol.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-11-20     Completed Date:  2007-04-20     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  101130615     Medline TA:  Vascul Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  221-6     Citation Subset:  IM    
Affiliation:
University of Pittsburgh School of Medicine, A 1207 Scaife Hall, Department of Medicine, Pittsburgh, PA 15261, United States. lbirder@pitt.edu
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MeSH Terms
Descriptor/Qualifier:
Analgesics, Non-Narcotic / pharmacology
Animals
Capsaicin / pharmacology
Fever / physiopathology
Humans
Models, Biological
Stress, Mechanical
TRPV Cation Channels / physiology
Urinary Bladder / cytology*,  drug effects,  physiology
Urothelium / cytology*,  drug effects,  physiology
Grant Support
ID/Acronym/Agency:
R01 DK54824/DK/NIDDK NIH HHS; R01 DK57284/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 0/TRPV Cation Channels; 0/TRPV1 protein, human; 404-86-4/Capsaicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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