| URINARY BLADDER PARAGANGLIOMA IN CHILDHOOD: A case report and review of the literature. | |
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MedLine Citation:
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PMID: 21385006 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Bladder paraganglioma (BP) is a rare entity, and is exceedingly uncommon in childhood. Pheochromocytomas/Paragangliomas are components of several hereditary cancer syndromes, and up to 30% may be associated with germ line mutations of genes including VHL, RET and SDH. We present a 16-year-old female who was admitted with macroscopic hematuria and anemia. A cystoscopy demonstrated a polypoid and hemorrhagic mass arising from the floor of the bladder. She underwent a transurethral resection of clinically suspected urothelial papilloma. A histologic examination of the tumor showed large polygonal cells with eosinophilic cytoplasm, arranged in a zellballen pattern, surrounded by a fibrous network. Immunohistochemical studies showed a strong expression of neuroendocrine markers and lack of reactivity for epithelial markers. The diagnosis of BP was established; eight months later, a recurrence was observed and the patient underwent a partial cystectomy. Our case is the first BP in childhood reported in the literature with absent SDHB staining by immunohistochemistry. We discuss the clinical and pathologic findings and present a review of BP in childhood. |
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Authors:
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Olga L Bohn; Edgar Pardo-Castillo; Mariana Fuertes-Camilo; Nina P Rios-Luna; Andres Martinez; Sergio Sanchez-Sosa |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-8 |
Journal Detail:
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Title: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Volume: - ISSN: 1093-5266 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9809673 Medline TA: Pediatr Dev Pathol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1 MetroHealth Medical Center. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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