| Urinary biomarkers suggest that estrogen-DNA adducts may play a role in the aetiology of non-Hodgkin lymphoma. | |
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MedLine Citation:
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PMID: 19630484 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A variety of evidence suggests that estrogens may induce non-Hodgkin lymphoma (NHL). The reaction of catechol estrogen quinones with DNA to form depurinating estrogen-DNA adducts is hypothesized to initiate this process. These adducts are released from DNA, shed from cells into the bloodstream and excreted in urine. The aim of this study was to determine whether or not the depurinating estrogen-DNA adducts might be involved in the aetiology of human NHL. Estrogen metabolites, conjugates and depurinating DNA adducts were identified and quantified in spot urine samples from 15 men with NHL and 30 healthy control men by using ultraperformance liquid chromatography/tandem mass spectrometry. The levels of estrogen-DNA adducts were significantly higher in the men with NHL than in the healthy control men. Thus, formation of estrogen-DNA adducts may play a critical role in the aetiology of NHL, and these adducts could be potential biomarkers of NHL risk. |
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Authors:
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Nilesh W Gaikwad; Li Yang; Dennis D Weisenburger; Julie Vose; Cheryl Beseler; Eleanor G Rogan; Ercole L Cavalieri |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2009-7-24 |
Journal Detail:
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Title: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals Volume: - ISSN: 1366-5804 ISO Abbreviation: Biomarkers Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-7-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9606000 Medline TA: Biomarkers Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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