| Urinary biomarkers of meat consumption. | |
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MedLine Citation:
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PMID: 21527577 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Meat intake has been positively associated with incidence and mortality of chronic diseases, including diabetes, heart disease, and several different cancers, in observational studies using self-report methods of dietary assessment; however, these dietary assessment methods are subject to measurement error. One method to circumvent such errors is the use of biomarkers of dietary intake, but currently there are no accepted biomarkers for meat intake. METHODS: We investigated four analytes (creatinine, taurine, 1-methylhistidine, and 3-methylhistidine) specifically found in meat and excreted in urine. Twenty-four hour urine samples were collected from 17 individuals on controlled diets containing varying levels of meats: vegetarian (0 g/day), low red meat (60 g/day), medium red meat (120g/day), and high red meat (420 g/day), as part of two randomized cross-over feeding studies. RESULTS: When compared to the low red meat diet or the vegetarian diet, the urinary levels of all four analytes were significantly higher in urine samples collected after 15 days of a high red meat diet (P<0.0001). Only urinary 1-methylhistidine and 3-methylhistidine were statistically significantly different for every diet type, increasing as the amount of meat in the diet increased (P<0.01 for 1-methylhistidine and P<0.05 for 3-methylhistidine). Furthermore, urinary excretion of 1-methylhistidine and 3-methylhistidine elevated with increasing meat intake in every individual. CONCLUSIONS: Urinary 1-methylhistidine and 3-methylhistidine may be good biomarkers of meat intake. Impact:To determine the public health impact of red meat on cancer risk, biomarkers are crucial to estimate true intake; these potential biomarkers should be further investigated in free-living populations. |
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Authors:
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Amanda J Cross; Jacqueline M Major; Rashmi Sinha |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-28 |
Journal Detail:
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Title: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Volume: - ISSN: 1538-7755 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200608 Medline TA: Cancer Epidemiol Biomarkers Prev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Division of Cancer Epidemiology & Genetics, National Cancer Institute. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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