Document Detail

Urinary biochemical markers of dietary intake in the INTERSALT study.
MedLine Citation:
PMID:  9094929     Owner:  NLM     Status:  MEDLINE    
The INTERSALT Study, an international, collaborative, cross-sectional investigation of the relation between blood pressure and dietary and other factors, used quality-controlled, standardized procedures and assessment of multiple possible confounding factors to study 10,079 men and women in 52 population-based samples in 32 countries. In this study 24-h urinary excretion data were used as biochemical markers of intakes of sodium, potassium, and protein, with repeat examinations done in a randomly selected 8% of participants to asses reliability and correct for regression-dilution bias. INTERSALT showed that high salt intake, low potassium intake, excess alcohol consumption, and energy imbalance resulting in overweight are critically involved in the origins of the high blood pressure prevalent among a majority of adult populations. The findings also show that obtaining accurate estimates of associations between dietary intake and blood pressure requires large population-based samples, high-quality dietary information, control for multiple confounding variables, and modern multivariate methods of data analyses, including correction of observed associations for within-person variation in intake.
A Dyer; P Elliott; D Chee; J Stamler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  65     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-04-30     Completed Date:  1997-04-30     Revised Date:  2010-08-25    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1246S-1253S     Citation Subset:  AIM; IM    
Department of Preventive Medicine, Northwestern University Medical School, Chicago, IL 60611-4402, USA.
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MeSH Terms
Biological Markers / urine*
Blood Pressure
International Cooperation
Middle Aged
Nutrition Assessment*
Potassium / administration & dosage,  urine
Sodium / administration & dosage,  urine
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Biological Markers; 7440-09-7/Potassium; 7440-23-5/Sodium

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