| Urinary beta-core human chorionic gonadotrophin: a new approach to Down's syndrome screening. | |
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MedLine Citation:
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PMID: 7534925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human chorionic gonadotrophin (hCG) is the most discriminatory maternal serum marker of Down's syndrome. We have carried out a study to establish whether urinary beta-core-hCG, a major metabolic product of hCG, might be an even better marker. Urine samples were available from seven singleton pregnancies with Down's syndrome, and one each of Edwards' syndrome, triploidy, and twins discordant for Down's syndrome. beta-Core-hCG levels were corrected for creatinine and expressed as multiples of the normal gestation-specific median (MOM) level derived from 67 singleton controls. There was a highly statistically significant elevation in level among the singleton Down's syndrome cases (P < 0.0005; Wilcoxon rank sum test). All had levels exceeding 2 MOM with a median of 6.11 MOM (95 per cent confidence interval 3.7-10.0). The levels were extremely low in Edwards' syndrome (0.08 MOM) and triploidy (0.02 MOM), but the twin pregnancy discordant for Down's syndrome did not have a raised beta-core-hCG level (0.64 MOM). The findings are sufficiently encouraging to investigate the possibility of urinalysis as a routine modality in the prenatal screening for Down's syndrome and other common serious aneuploidies. |
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Authors:
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H S Cuckle; R K Iles; T Chard |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prenatal diagnosis Volume: 14 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 1994 Oct |
Date Detail:
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Created Date: 1995-04-27 Completed Date: 1995-04-27 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 953-8 Citation Subset: IM |
Affiliation:
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Department of Clinical Medicine, University of Leeds, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aneuploidy Chorionic Gonadotropin / urine* Chorionic Gonadotropin, beta Subunit, Human Down Syndrome / diagnosis*, genetics, urine Female Fetal Diseases / diagnosis*, genetics, urine Genetic Testing Humans Linear Models Peptide Fragments / urine* Pregnancy Prenatal Diagnosis* |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/Peptide Fragments |
| Comments/Corrections | |
Comment In:
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Prenat Diagn. 1996 Nov;16(11):1057-9
[PMID:
8953643
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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