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Urinary aquaporin-2 excretion during ibuprofen or indomethacin treatment in preterm infants with patent ductus arteriosus.
MedLine Citation:
PMID:  20626367     Owner:  NLM     Status:  Publisher    
ABSTRACT Aim: Water channel AQP2 is the target for vasopressin and a major determinant of urinary concentrating capacity. In mature kidneys, prostaglandins counteract the effect of vasopressin on AQP2 expression at functional sites. We investigated whether disturbances in water homeostasis in infants with patent ductus arteriosus (PDA) treated with prostaglandin inhibitors, can be attributed to activation of AQP2. Methods: In 53 infants with symptomatic PDA (gestational age 24-33 weeks), 30 receiving ibuprofen and 23 indomethacin starting at 2-15 days of life, clinical and biochemical data were collected before treatment and after each dose of the drugs. Urinary AQP2 was determined by dot immunoblotting. Results: Urinary AQP2 level and osmolality were decreased in both groups. Urinary osmolality was overall low and correlated inversely with fluid uptake. In ibuprofen group, there was no correlation of AQP2 level with urinary osmolality. Conclusion: There was no AQP2 upregulation in the infants. The low urinary osmolality and dissociation between urinary osmolality and urinary AQP2 level indicate that the fluid retention sometimes observed in PDA infants treated with prostaglandin inhibitors is not caused by increased levels of functional AQP2. Thus, knowledge about the renal physiology of the adult can not always be transferred to the infant kidney.
Yanhong Li; Marina Zelenina; Geneviève Plat-Willson; Marie-Odile Marcoux; Anita Aperia; Charlotte Casper
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-7-08
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  -     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-7-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
. Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden Nordic Centre of Excellence for Research in Water Imbalance Related Disorders (WIRED), Stockholm, Sweden.
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