| Urinary angiotensinogen excretion and ambulatory blood pressure. | |
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MedLine Citation:
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PMID: 22871893 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Previous studies have demonstrated that urinary angiotensinogen excretion, a biomarker of the intrarenal renin-angiotensin system activity, is associated with clinic blood pressure (BP). In the present study, we investigated the determinants of urinary angiotensinogen excretion and its associations with ambulatory BP. METHODS: The study participants were suspected hypertensive patients being off antihypertensive medication for at least 2 weeks and referred to our hypertension clinic for 24-h ambulatory BP monitoring. Ambulatory hypertension was defined as a 24-h BP of at least 130 mmHg systolic or 80 mmHg diastolic. We collected a first morning urine sample for the measurement of angiotensinogen by ELISA kits. RESULTS: The 446 participants (mean age 51.7 years) included 218 (48.9%) men, and 275 (61.7%) patients had ambulatory hypertension. In addition to age and sex, 24-h urinary sodium excretion was an independent determinant of urinary angiotensinogen-to-creatinine ratio (P = 0.0008). Urinary angiotensinogen-to-creatinine ratio was 34% (P = 0.04) and 82% (P ≤ 0.0001) higher in tertiles 2 and 3 of 24-h urinary sodium excretion, respectively, than in tertile 1. In multivariate analyses, urinary angiotensinogen-to-creatinine ratio was significantly and positively associated with clinic and ambulatory BP (P ≤ 0.02) and the prevalence of ambulatory hypertension [odds ratio (95% confidence interval) associated with two-time increase, 1.24 (1.09-1.39); P = 0.0007]. CONCLUSION: Urinary angiotensinogen excretion is higher with greater urinary sodium excretion, and is associated with clinic and ambulatory BP. |
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Authors:
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Jun Zou; Yan Li; Fa-Hong Li; Fang-Fei Wei; Ji-Guang Wang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hypertension Volume: 30 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-09-14 Completed Date: 2013-01-25 Revised Date: 2013-04-15 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 2000-6 Citation Subset: IM |
Affiliation:
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Centre for Vascular Evaluations and Centre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensinogen
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urine* Blood Pressure Monitoring, Ambulatory* Creatinine / urine Female Humans Hypertension / diagnosis*, physiopathology, urine Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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11002-13-4/Angiotensinogen; 60-27-5/Creatinine |
| Comments/Corrections | |
Comment In:
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J Hypertens. 2013 Apr;31(4):840
[PMID:
23466894
]
J Hypertens. 2013 Apr;31(4):840-1 [PMID: 23466895 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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