Document Detail

Urinary angiotensinogen excretion and ambulatory blood pressure.
MedLine Citation:
PMID:  22871893     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Previous studies have demonstrated that urinary angiotensinogen excretion, a biomarker of the intrarenal renin-angiotensin system activity, is associated with clinic blood pressure (BP). In the present study, we investigated the determinants of urinary angiotensinogen excretion and its associations with ambulatory BP.
METHODS: The study participants were suspected hypertensive patients being off antihypertensive medication for at least 2 weeks and referred to our hypertension clinic for 24-h ambulatory BP monitoring. Ambulatory hypertension was defined as a 24-h BP of at least 130  mmHg systolic or 80  mmHg diastolic. We collected a first morning urine sample for the measurement of angiotensinogen by ELISA kits.
RESULTS: The 446 participants (mean age 51.7 years) included 218 (48.9%) men, and 275 (61.7%) patients had ambulatory hypertension. In addition to age and sex, 24-h urinary sodium excretion was an independent determinant of urinary angiotensinogen-to-creatinine ratio (P = 0.0008). Urinary angiotensinogen-to-creatinine ratio was 34% (P = 0.04) and 82% (P ≤ 0.0001) higher in tertiles 2 and 3 of 24-h urinary sodium excretion, respectively, than in tertile 1. In multivariate analyses, urinary angiotensinogen-to-creatinine ratio was significantly and positively associated with clinic and ambulatory BP (P ≤ 0.02) and the prevalence of ambulatory hypertension [odds ratio (95% confidence interval) associated with two-time increase, 1.24 (1.09-1.39); P = 0.0007].
CONCLUSION: Urinary angiotensinogen excretion is higher with greater urinary sodium excretion, and is associated with clinic and ambulatory BP.
Jun Zou; Yan Li; Fa-Hong Li; Fang-Fei Wei; Ji-Guang Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  30     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-14     Completed Date:  2013-01-25     Revised Date:  2013-04-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  2000-6     Citation Subset:  IM    
Centre for Vascular Evaluations and Centre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
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MeSH Terms
Angiotensinogen / urine*
Blood Pressure Monitoring, Ambulatory*
Creatinine / urine
Hypertension / diagnosis*,  physiopathology,  urine
Middle Aged
Reg. No./Substance:
11002-13-4/Angiotensinogen; 60-27-5/Creatinine
Comment In:
J Hypertens. 2013 Apr;31(4):840   [PMID:  23466894 ]
J Hypertens. 2013 Apr;31(4):840-1   [PMID:  23466895 ]

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