| Urinary ammonia and ammonia-producing microorganisms in infants with and without diaper dermatitis. | |
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MedLine Citation:
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PMID: 596897 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Free ammonia was determined in diaper squeezings from 26 infants with "ammoniacal dermatitis" and in 82 controls. No significant difference was found (402 ppm in diaper dermatitis compared to 465 in controls). The groups did not differ with regard to the incidence of organisms capable of splitting ammonia from urea. Experimental application of highly ammoniacal urine on intact infant and adult skin failed to provoke a dermatitis. Erythema could be induced only when ammoniacal urine was applied occlusively to scarified skin. These findings do not support the notion that ammonia is a primary factor in common diaper rash, but do not exclude a possible role for further irritation in an already existent condition. |
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Authors:
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J J Leyden; S Katz; R Stewart; A M Kligman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of dermatology Volume: 113 ISSN: 0003-987X ISO Abbreviation: Arch Dermatol Publication Date: 1977 Dec |
Date Detail:
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Created Date: 1978-02-18 Completed Date: 1978-02-18 Revised Date: 2008-03-17 |
Medline Journal Info:
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Nlm Unique ID: 0372433 Medline TA: Arch Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1678-80 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ammonia
/
adverse effects,
metabolism,
urine* Bacteria / metabolism Brevibacterium / metabolism Child, Preschool Diaper Rash / chemically induced, etiology*, microbiology Erythema / chemically induced Humans Infant Skin / drug effects Urea / metabolism |
| Chemical | |
Reg. No./Substance:
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57-13-6/Urea; 7664-41-7/Ammonia |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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