Document Detail

Urinary ammonia and ammonia-producing microorganisms in infants with and without diaper dermatitis.
MedLine Citation:
PMID:  596897     Owner:  NLM     Status:  MEDLINE    
Free ammonia was determined in diaper squeezings from 26 infants with "ammoniacal dermatitis" and in 82 controls. No significant difference was found (402 ppm in diaper dermatitis compared to 465 in controls). The groups did not differ with regard to the incidence of organisms capable of splitting ammonia from urea. Experimental application of highly ammoniacal urine on intact infant and adult skin failed to provoke a dermatitis. Erythema could be induced only when ammoniacal urine was applied occlusively to scarified skin. These findings do not support the notion that ammonia is a primary factor in common diaper rash, but do not exclude a possible role for further irritation in an already existent condition.
J J Leyden; S Katz; R Stewart; A M Kligman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of dermatology     Volume:  113     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  1977 Dec 
Date Detail:
Created Date:  1978-02-18     Completed Date:  1978-02-18     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1678-80     Citation Subset:  AIM; IM    
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MeSH Terms
Ammonia / adverse effects,  metabolism,  urine*
Bacteria / metabolism
Brevibacterium / metabolism
Child, Preschool
Diaper Rash / chemically induced,  etiology*,  microbiology
Erythema / chemically induced
Skin / drug effects
Urea / metabolism
Reg. No./Substance:
57-13-6/Urea; 7664-41-7/Ammonia

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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