Document Detail


Urinary amines in Tourette's syndrome patients with and without phenylethylamine abnormality.
MedLine Citation:
PMID:  2333359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous data indicated a subgroup of Tourette's syndrome patients with a beta-phenylethylamine (PEA) level that was lower than all subjects in a control group matched for age and education. The current study compared the subgroups of Tourette's syndrome patients (n = 28) from the previous study with 20 control subjects in regard to other amines and metabolites. Patients with low levels of PEA were also found to have lower levels of 3-methoxy-4-hydroxy-phenylglycol, normetanephrine, serotonin, m-tyramine, and p-tyramine. There was also some evidence of dopaminergic abnormalities in the low-PEA subgroup. These data provide suggest a role of PEA in the pathophysiology of some patients with Tourette's syndrome. This effect may be mediated through other neurotransmitter systems.
Authors:
R A Bornstein; G B Baker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Psychiatry research     Volume:  31     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-06-05     Completed Date:  1990-06-05     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  279-86     Citation Subset:  IM    
Affiliation:
Neuropsychology Laboratory, Ohio State University, Columbus 43210.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Biogenic Amines / urine*
Child
Female
Humans
Male
Phenethylamines / urine*
Tourette Syndrome / diagnosis,  urine*
Grant Support
ID/Acronym/Agency:
MH-42209/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Biogenic Amines; 0/Phenethylamines; 64-04-0/phenethylamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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